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ARL15基因rs4311394多态性与非小细胞肺癌遗传易感性的关联 被引量:1

Association Study of ARL 15 Gene rs4311394 Polymorphisms and Genetic Predisposition of Non-small Cell Lung Cancer
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摘要 目的探讨ADP-核糖基化样因子15(ADP—ribosylation factor like 15,ARL15)基因多态性与非小细胞肺癌(non-small cell lung cancer,NSCLC)的相关性.方法采用Taq Man基因分型方法对NSCLC患者(n=359)与健康体检人群(n=376)进行ARL 15基因SNP-rs4311394位点基因分型,评估这个单核苷酸多态性(single nucleotide polymorphism,SNP)与NSCLC发生的相关性,同时根据NSCLC病理类型和恶性程度进行分层分析,评估这个位点与NSCLC病理类型和恶性程度的相关性.结果 ARL15基因SNP-rs 4311394位点基因型和等位基因频率在NSCLC组和对照组中差异无统计学意义(P>0.05);在NSCLC鳞癌和腺癌中SNP-rs4311394位点基因型和等位基因频率分布差异无统计学意义(P>0.05);同时,SNP-rs4311394位点基因型和等位基因频率分布于NSCLC恶性程度也无相关性.结论 ARL15基因SNP-rs4311394与NSCLC的发生、病理类型及临床分期无相关性. Objective This study aimed to investigate the association of polymorphisms in ARL 15 (ADP-ribosylation factor like 15) gene and non-small cell lung cancer (NSCLC) Methods 359 patients with NSCLC and 376 healthy controls in Chinese Han were included in present study. SNP-rs4311394 in ARL ]5 gene was genotyped using TaqMan technique. The correlations of the SNPs with NSCLC pathologic types and clinical stages were evaluated. Results The genotypic and allelic frequencies of SNP-rs4311394 showed no significant difference between NSCLC and the control groups (P 〉 0.05) . The genotypic and allelic frequencies of SNP-rs4311394 showed no significant difference between the squamous carcinoma and the adenoearcinoma groups (P 〉 0.05) . The genotypic and allelic frequencies of SNP-rs4311394 showed no significant difference between the stage Ⅰ+Ⅱ and stage Ⅲ+Ⅳ groups (P 〉 0.05). Conclusion ARL 15 SNP-rs4311394 was not associated with the occurence, pathologic types and clinical stages of NSCLC.
出处 《昆明医科大学学报》 CAS 2015年第4期53-56,共4页 Journal of Kunming Medical University
基金 云南省卫生科技计划项目(2014NS139) 云南省应用基础研究基金资助项目(2012FB064)
关键词 非小细胞肺 ARL15 多态性 Carcinoma Non-small-cell lung ADP-ribosylation factor like 15 Polymorphism
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参考文献15

  • 1LAWRENCE R E,SALGIA R. MET molecular mecha- nisms and therapies in lung cancer [ J ]. Cell Adh Migr,2010, 4 (1):146-152.
  • 2WILLIAMS C J,MITSIADES N,SOZOPOULOS E,et al. Adiponeetin receptor expression is elevated in eolorectal carcinomas but not in gastrointestinal stromal tumors [ J ]. Endocr Relat Cancer, 2008,15 ( 1 ) : 289- 299.
  • 3DAL MASO L,AUGUSTIN L S,KARALIS A,et al. Circu- lating adiponectin and endometrial cancer risk [J]. J Clin Endocrinol Metab, 2004,89 (3) : 1 160- 1 163.
  • 4HORIGUCHI A,ITO K,SUMITOMO M,et al. Decreased serum adiponeetin levels in patients with metastatic renal cell carcinoma [J]. Jpn J Clin Oncol,2008,38 (2): 106-111.
  • 5ISHIKAWA M, KITAYAMA J, KAZAMA S,et al. Plasma adiponectin and gastric cancer [J]. Clin Cancer Res, 2005, 11 (2):466-472.
  • 6MIYOSHI Y, FUNAHASHI T, KIHARA S, et al. Associa- tion of serum adiponectin levels with breast cancer risk [J ]. Clin Cancer Res, 2003,9 (15): 5 699-5 704.
  • 7李盈甫,钱旭,周竞贤,陈楠,虎月燕,马千里.脂联素基因多态性与非小细胞肺癌遗传易感性的关联[J].昆明医科大学学报,2014,35(9):52-55. 被引量:3
  • 8RICHARDS J B, WATERWORTH D, RAHILLY S, et al.A genome wide as sociation study reveals variants in ARI. 1 5 that influence adiponeetin levels [J]. PLoS Genet, 2009,5 (12): 1 000768.
  • 9高俊珍,付秀华,王立红,李国华,徐常丽.无症状肺癌的临床特点及其诊断方法分析[J].中华临床医师杂志(电子版),2012,6(4):143-145. 被引量:10
  • 10马云川.PET概述及其在肺癌诊疗中的应用(VCD)[J].中华临床医师杂志(电子版),2008,2(11):58-58. 被引量:3

二级参考文献91

  • 1吕嘉林,郑华,仝丽,胡瑛,张同梅,李雪冰,张红梅,孙怡芬,王敬萍,李宝兰.70岁以上老年人肺癌确诊途径及临床特征的分析[J].中华临床医师杂志(电子版),2011,5(16):4870-4872. 被引量:1
  • 2林海龙,崔社怀,段绪伟.重庆地区无症状性肺癌的临床分析[J].中国康复理论与实践,2005,11(3):226-227. 被引量:3
  • 3Yamamoto Y, Hirose H, Saito I, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond),2002,103:137 142.
  • 4Nishizawa H, Shimomura I, Kishida K, et al. Androgens decrease plasma adiponectin, an insulin sensitizing adipoeyte derived protein. Diabetes,2002,51 =2734 2741.
  • 5Ishikawa M, Kitayama J, Kazama S, et al. Plasma adiponectin and gastric cancer. Clin Cancer Res, 2005,11 (2 Pt 1) :466-472.
  • 6Wei EK, Giovannucci E, Fuehs CS, et al. I.ow plasma adiponectin levels and risk o{ colorectal cancer in men: a prospective study. J Natl Cancer Inst, 2005,97 : 1688 1694.
  • 7Goktas S, Yilmaz MI, Caglar K, et al. Prostate cancer and adiponec/Lin. Urology, 2005,65 .. 1168 1172.
  • 8Miyoshi Y, Funahashi T, Kihara S, et al. Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res,2003,95699 5704.
  • 9Brfikerlhielm E, Veitonmgki N, Cao R, et al. Adiponectin- induced antiangiogenesis and antitumor activity involve caspase mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A,2004,101:2476-2481.
  • 10Frasca F, Pandini G, Sciacca L, et al. The role of insulin receptors and IGF I receptors in cancer and other diseases. Arch Physiol Biochem, 2008,114 23-37.

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