摘要
目的：探讨围绝经期妇女血清中促卵泡激素（FSH）水平与骨代谢指标总Ⅰ型前胶原氨基端延长肽（ TP1NP）的相关性。方法：选取2011年8月—2012年11月在浙江大学医学院附属妇产科医院就诊的围绝经期妇女274例，年龄33～60岁。应用电化学发光法检测妇女血清FSH和TP1 NP水平，并应用多重线性回归模型分析围绝经期妇女的年龄、FSH及TP1 NP因素间的相关性。结果：274例围绝经期妇女的TP1NP平均水平为（48．99±20．31）ng／mL，且FSH水平与TP1NP水平呈正相关（ r＝0．159，P＝0．009）。在40～50岁妇女中，FSH水平＜40 mIU／mL者的 TP1NP 水平低于 FSH ＞40 mIU／mL 者[（35．05±18．11） ng／mL 与（51．33±24．67） ng／mL；t＝－2．954， P＝0．004]；而在小于40岁和51～60岁妇女中，不同FSH水平下TP1NP水平差异无统计学意义（ t＝－0．063， P＝0．950；t＝1．177， P＝0．242）。多重线性回归模型分析显示年龄变量标准化偏回归系数为0．047（ P＝0．448），而FSH变量标准化偏回归系数为0．146（ P＝0．019） ，可见FSH水平比年龄变量对TP1 NP的影响更大。结论：围绝经期妇女TP1 NP水平与FSH呈现一定相关性，尤其是对于40～50岁的妇女，高FSH可能是引起绝经后骨质疏松的重要因素。
Objective：To investigate the correlation between serum levels of follicle-stimulating hormone （ FSH） and total procollagen I N-terminal propeptide （ TP1NP） in perimenopausal women .Methods：Total 274 women aged 33～60 y with perimenopausal period were enrolled in this study .Serum levels of FSH and TP1NP were detected by electrochemiluminescence .Results：In 274 perimenopausal women , the average level of TP1NP was （48.99 ±20.31） ng/mL, which was positively correlated with FSH level （r=0.159, P=0.009）.In 40-50 age group, TP1NP level in women with FSH〈40 mIU/mL was lower than that in those with FSH≥40mIU/mL [（35.05 ±18.11） ng/mL vs （51.33 ±24.67） ng/mL; t =-2.954, P =0.004].However, in 〈40 and 50-60 age groups, there were no significant differences in TP 1NP levels between patients with FSH〈40 mIU/mL and those with FSH≥40 mIU/mL （ t=-0 .063 , P=0 .950;t =1 .177 , P =0 .242 ） . Multiple linear regression analysis showed that standardized coefficients of age variable was 0 .047 （ P =0 .448 ） and standardized coefficients of FSH variable was 0.146 （ P =0.019 ）.Conclusion： TP1NP levels showed a certain correlation with FSH in perimenopausal women , especially for women aged 40～50 , indicating that high FSH levels may be important factors for osteoporosis in postmenopausal women .
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2015年第1期85-89,共5页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金(81370685)
浙江省级公益性技术应用研究计划(2013C33152)
关键词
围绝经期
卵泡刺激素
前胶原/血液
肽类/血液
胶原Ⅰ型/血液
骨质疏松
绝经后
Perimenopause
Follicle stimulating hormone/blood
Procollagen/blood
Peptides/blood
Collagen type I/blood
Osteoporosis,postmenopausal
