摘要
目的探讨头孢地嗪对老年细菌性肺炎患者外周血T淋巴细胞CD4/CD8和Th1/Th2细胞比例的影响。方法选取老年细菌性肺炎患者63例,以随机数字表分为两组;对照组31例采用头孢三嗪静脉滴注疗法,观察组32例采用头孢地嗪静脉滴注疗法治疗。分别于治疗前后抽取患者空腹静脉血,以流式细胞仪测定CD4/CD8和Th1/Th2的细胞计数比;以ELISA试剂盒测定Th1细胞分泌因子白细胞介素2(IL-2)、γ干扰素(IFN-γ)与Th2细胞分泌因子IL-4、IL-10的血清浓度。结果治疗前,两组患者的各项指标均无明显差异。治疗后,观察组患者CD4+细胞、Th1细胞比例增加,Th2细胞比例降低,CD4/CD8和Th1/Th2比值均显著高于对照组;同时,观察组患者血清IL-2、IFN-γ浓度显著高于对照组,IL-4、IL-10浓度显著低于对照组。结论头孢地嗪能够提高老年细菌性肺炎患者细胞免疫功能,纠正外周血T淋巴细胞CD4/CD8和Th1/Th2比例失调。
Objective To explore the influence of cefodizime on CD4/CD8 and T helper 1（Th1） /Th2 cel ratios in peripheral blood of the senile patients with bacterial pneumonia.Methods Sixty-three senile patients with bacterial pneumonia were enrolled and divided into two groups randomly.Patients in the control group（n = 31） were given intravenous infusion of ceftriaxone sodium,and patients in the observation group（n = 32） were given intravenous infusion of cefodizime.The fasting venous blood was taken before and after treatment to detect CD4 / CD8 and Th1 / Th2 cell ratios with flow cytometry.At the same time,the serum interleukin-2（IL-2）,interferon γ（IFN-γ）,IL-4 and IL-10 contents were also detected with ELISA.Results Before treatment,there was no significant difference in the above indexes between the two groups.After treatment,CD4＋cells and Th1 cells of the observation group increased while Th2 cells decreased; as a result,the CD4 / CD8 and Th1 / Th2 cell ratios of the observation group were significantly higher than those of the control group.At the same time,serum IL-2 and IFN-γ contents of the observation group were significantly higher than those of the control group,while serum IL-4 and IL-10 contents were significantly lower than those of the control group.Conclusion Cefodizime can improve the cellular immune function and rectify CD4 / CD8 and Th1 / Th2 imbalance in peripheral blood of the senile patients with bacterial pneumonia.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2015年第4期528-531,共4页
Chinese Journal of Cellular and Molecular Immunology
