摘要
目的:探讨丙泊酚中/长链脂肪乳注射液用于剖宫产全麻的应用价值及其安全性,为临床合理用药提供参考。方法:丙泊酚中/长链脂肪乳注射液用于剖宫产全麻诱导,对比观察全身麻醉和硬膜外麻醉对产妇血液动力学及新生儿脐血血气和Apgar评分的影响,选择ASAⅠ-Ⅱ级足月妊娠初产妇60例,随机分为全身麻醉组(M组)和硬膜外麻醉组(E组),每组各30例。分别记录产妇入室后(T0)、麻醉诱导(T1)、手术切皮时(T2)、胎儿剖出即刻(T3)等时点的脉搏血氧饱和度(SpO2)、平均动脉压(MAP)、心率(HR)的变化。两组产妇均在新生儿娩出时抽取脐动、静脉血,进行血气分析,分别记录两组切皮至新生儿娩出时间(S-DI)、子宫切开至新生儿娩出时间(U-DI)、新生儿出生1min和5min Apgar评分。结果:全麻组和硬膜外组的S-DI时间分别为(5.4±1.5)min和(10.1±2.2)min,两组相比差异有显著意义(P<0.05),U-DI时间两组相比差异无统计学意义(P>0.05)。全麻组和硬膜外组新生儿脐动、静脉血血气分析和新生儿出生1 min和5 min Apgar评分两组比较,差异均无统计学意义(P>0.05)。结论:丙泊酚中/长链脂肪乳注射液2.0mg/kg切皮前单次静脉推注应用于剖宫产全麻诱导是安全有效的,母体血液动力学控制理想,对新生儿脐血血气和Apgar评分无明显影响。
Objective:To explore value and safety of propofol medium and long chain fat emulsion injection of general anesthesia for cesarean delivery,and provide reference for further clinical rational drug use.Methods:Sixty ASA Ⅰ-Ⅱ full-term pregnancy mothers were randomly divided into general anesthesia group(group M)and epidural anesthesia group(group E),with 30 cases in each group.Maternal pulse oxygen saturation(SpO2),mean arterial pressure(MAP),heart rate(HR)after admission into the operation room(T0),anesthesia induction(T1),skin incision(T2)and fetal cutting out(T3)were recorded.Umbilical cord blood samples were collected after neonatal childbirth for blood gas analysis.The cut skin to neonatal childbirth time(S-DI),uter-ine incision to the childbirth time(U-DI)and newborn babies' Apgar score of 1min and 5min were recorded.Results:Compared with group E,S-DI significantly decreased in group M(P〈0.05),there was no statistically significant difference in U-DI between the two groups(P〈0.05).No statistical differences were found in umbilical cord blood gas analysis and Apgar score between the two groups(P〈0.05).Conclusion:It is safe and effective to use propofol medium and long chain fat emulsion injection(2.0mg/kg)in the induction of general anesthesia for cesarean delivery,in which maternal blood dynamics control is ideal,and umbilical cord blood gas analysis and Apgar score have no obvious changes.
出处
《武汉大学学报(医学版)》
CAS
2015年第3期451-454,共4页
Medical Journal of Wuhan University
基金
贵州省卫生厅基金项目(编号:gzwkj2010-1-006)
贵州省科技厅基金项目(编号:黔科SY字[2012]3090号)
关键词
丙泊酚中/长链脂肪乳注射液
剖宫产
全麻
Propofol Medium and Long Chain Fat emulsion Injection
Cesarean Section
General Anesthesia