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煅烧骨复合PRF对牙周骨缺损的实验研究 被引量:1

Empirical Study of Reparation of Periodontal Bone Defects Treated with PRP and Calcined Bone Composite.
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摘要 目的:研究比较异种煅烧骨和Bio-oss骨分别与富血小板纤维蛋白(platdet-rich fibrin,PRF)联合,及其各自单独使用对牙周骨缺损修复的效果。方法:制备煅烧骨,PRF凝胶及其复合物。选54只新西兰大白兔,制备牙周组织缺损模型,随机分成空白对照组、PRF凝胶组、煅烧骨组、Bio-oss骨组、煅烧骨/PRF凝胶组、Bio-oss骨/PRF凝胶组,将这些材料植入牙周缺损区,每组9只兔子。术后4周、8周和l2周处死动物,获取完整标本,观察影像学和组织学。行组织学染色检测,测量新生牙周组织的高度。结果:X线结果表明:4周、8周和l2周煅烧骨/PRF组和Bio-oss/PRF组平均密度均明显高于对照组且缺损处骨组织连续。组织学观察:实验组均在牙根面可见新生牙骨质样组织、牙周膜和牙槽骨样组织的形成,随着时间的推移逐渐成熟、增多。12周时,煅烧骨/PRF凝胶、Bio-oss骨/PRF凝胶较空白对照组明显提高,较其他3组差异有统计学意义(P<0.05)。结论:煅烧骨/PRF凝胶、Bio-oss骨/PRF凝胶复合物可明显促进牙周组织的再生。 Objective:To study the dissimilar calcined bone and Bio-oss bone respectively,and composite with platelet rich fibrin(platdet-rich fibrin,PRF),and their respective alone on the effect of periodontal bone defects.Methods:Calcined bone,PRF gel and complex were prepared.54 rabbits were selected.Periodontal tissue defect model was randomly divided into control group,PRF gel group,calcined bone group,Bio-oss bone group,calcined bone/PRF group,Bio-oss bone/PRF group.After four weeks,eight weeks and l2 weeks the animals were sacrificed for a complete specimen,radiological and histological observation.Histological staining was used to measure the height of newborn periodontal tissues.Results:X-ray results showed that:4weeks,8weeks and l2 weeks calcined bone/PRF group and Bio-oss/PRF group were significantly higher than the average density,and bone tissue defects continuously.The experimental group was seen in root surfaces like tissue formation of new cementum,periodontal ligament and alveolar bone-like tissue matures over time,increasing.12 weeks,the calcined bone/PRF,Bio-oss bone/PRF significantly improved compared with the control group,compared with the other three groups were statistically significant(P〈0.05).Conclusion:Calcined bone/PRF gel and Bio-oss bone/PRF gel complexes can significantly promote the regeneration of periodontal tissues.
出处 《口腔医学研究》 CAS CSCD 北大核心 2015年第4期332-335,339,共5页 Journal of Oral Science Research
基金 新疆维吾尔自治区科技厅科技支疆项目(编号:201291173) 新疆医科大学第一附属医院青年基金项目(编号:2012QN21)
关键词 富血小板纤维蛋白 煅烧骨 牙周组织再生 Platelet-rich fibrin Calcined bone Periodontal tissue regeneration
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参考文献11

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