摘要
目的:研究青年ST段抬高型心肌梗死(STEMI)患者中胱抑素C(Cys C)的含量的变化。方法:入选2010-2012年在郑州大学第一附属医院以及郑州大学附属洛阳中心医院接受急诊PCI的STEMI和冠状动脉(冠脉)造影正常的青年患者(年龄<45岁),STEMI组220例患者,对照组为350例冠脉造影正常的青年患者,将两组患者资料进行对照分析。结果:青年STEMI组Cys C高于对照组[(1.34±0.21)mg/dl∶(0.75±0.13)mg/dl,P<0.05],而两组肌酐未见明显差异[(0.89±0.3)mg/dl∶(0.80±0.4)mg/dl],P>0.05)。将两变量Cys C及hs-CRP进行直线相关分析,提示两者存在正相关(r=0.635,P<0.01)。多元Logistic回归分析发现,Cys C为青年发生STEMI的独立危险因素(OR:2.408,P=0.001)。结论:青年STEMI患者的Cys C水平明显升高,Cys C可能参与青年STEMI的发生。
Objective：To investigate the Cystain C level in young patients with acute ST-segment elevation myocardial infarction（STEMI）.Method：This study included 220 young patients who presented to our hospital with acute myocardial infarction（age 45years old）and 350 adults with normal coronary angiography as control group.Result：Compared with control group,STEMI group had a significantly higher value of Cys C [（1.34±0.21）mg/dl vs（0.75±0.13）mg/dl,P〈0.05].Value of creatinine was similar in both of two groups[（0.89±0.3）mg/dl vs（0.80±0.4）mg/dl,P〈0.05].The level of Cys C was positively correlated with hs-CRP（r=0.635,P〈0.01）.After multivariate analysis,high level of Cys C was an independent predictor of STEMI in young patients（OR：2.408,P=0.001）.Coclusion：The Cys C level is higher in young patients with STEMI than control group.It probably involves in the occurrence of STEMI in young patients.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第4期404-406,共3页
Journal of Clinical Cardiology
关键词
胱抑素C
青年
急性心肌梗死
cystatin C
young patients
acute myocardial infarcion
