摘要
目的探讨亚洲人群谷胱甘肽巯基转移酶基因GSTM1无效基因型与膀胱癌易感性的关系。方法检索PubMed、EMBase、CBM、CNKI、VIP、万方数据平台从建库到2014年9月1日的文献,对所纳入的研究,运用RevMan 5.2软件进行Meta分析。结果共纳入18篇病例对照研究,累计样本量为5 992例,其中膀胱癌病例组2 618例,对照组3 374例。Meta分析结果可见亚洲人群中GSTM1无效基因型与膀胱癌易感性呈显著性正相关（OR=1.48,95%CI=1.33-1.65,P〈0.000 01）。亚组分析提示,土耳其人群、东亚人群及中国人群中,GSTM1无效基因型均显示出能显著增加膀胱癌易感性（OR=1.31,95%CI=1.06-1.62,P=0.01;OR=1.56,95%CI=1.37-1.78,P〈0.000 01;OR=1.61,95%CI=1.34-1.93,P〈0.000 01）。漏斗图提示各文献间未见明显发表偏倚。结论在亚洲人群中GSTM1无效基因型与膀胱癌易感性可能存在呈正相关。
Objective To explore the association between GSTM1 polymorphism and bladder cancer in Asian people. Methods Databases,including PubMed,EMBase,CBM,CNKI,VIP,Wanfang Data,were searched to get related studies.Data analysis was conducted by Revman 5.2software. Results Eighteen case-control studies were included.Totally,using M-H method in the fixed-effects model,the GSTM1 null genotype was associated with bladder cancer in Asian people（OR=1.48,95%CI=1.33-1.65,P〈0.000 01）.In subgroup analysis,the GSTM1 null genotype was associated with bladder cancer in Turkish,East Asian and Chinese people（OR=1.31,95%CI=1.06-1.62,P=0.01;OR=1.56,95%CI=1.37-1.78,P〈0.000 01;OR=1.61,95%CI=1.34-1.93,P〈0.000 01）.There was no existence of publication bias. Conclusions This meta-analysis suggests that there may be a relationship between the GSTM1 null genotype and bladder cancer in Asian people.
出处
《现代泌尿生殖肿瘤杂志》
2015年第1期22-26,共5页
Journal of Contemporary Urologic and Reproductive Oncology
基金
深圳市龙岗区2014年度科技计划医疗卫生项目(201406093001004)
