摘要
目的分析北京某三甲综合性医院2011—2013年住院患者质子泵抑制剂(proton pump inhibitor,PPI)的应用情况。方法对该院3年间住院患者应用PPI的品种、消耗金额、用药频度(DDDs)、日均费用(DDDc)等情况进行统计和分析。结果该院2011—2013年住院患者PPI全年总消耗金额呈增长趋势,且占年药品消耗金额比例逐年增加,由2011年的1.81%增长至2013年的2.31%,其中奥美拉唑的消耗金额始终排在前列,但年增长率有所下降。3年间埃索美拉唑口服剂使用频度较高,注射用奥美拉唑DDDs排序上升幅度较大,泮托拉唑、雷贝拉唑口服剂DDDs排序不断下降。以奥美拉唑和埃索美拉唑口服剂序号比值>1的情况最为突出,大多数PPI的DDDc逐年下降。外科PPI使用率逐年升高。结论胃酸分泌相关性消化系统疾病发病率呈上升趋势,第一代PPI在临床用药中仍占主要地位,但是已有被第二代取代的趋势。该院PPI临床用药基本合理,但在外科应用中尚需进一步加强规范使用适应证。
Objective To analyze the applications of proton pump inhibitors（ PPI） in a comprehensive Three-A level hospital in Beijing from 2011 to 2013. Methods The variety,sales amount,DDDs and the average daily cost（ DDDc） of PPI were analyzed statistically. Results The total amount of sales of PPI in the inpatient department during 2011-2013 showed a growing trend,and the proportion of proton pump inhibitors in all the medications increased year by year,from 1. 81% in2011 to 2. 31% in 2013. Esomeprazole rose significantly among the total,but the growth rate of omeprazole declined. From the DDDs ordering,the utilization of peroral dosage form of esomeprazole was higher in these three years,meanwhile,the growth range of omeprazole injection was comparatively larger. The peroral dosage form of pantoprazole and rabeprazole showed a declining trend in DDDs ordering. An investigation showed that utilization of PPI in surgery was growing year by year. Conclusion The incidence rate of peptic ulcer disease is rising,the first generation of proton pump inhibitors in clinical medicine still occupies a dominant position,but there is a trend that it is being replaced by second generation gradually. The clinical medicine on proton pump inhibitors（ PPI） in the hospital is generally reasonable,but the use of drug in surgery should be standardized.
出处
《临床误诊误治》
2015年第4期103-107,共5页
Clinical Misdiagnosis & Mistherapy
