摘要
目的比较三种不同药物治疗恶性胸腔积液的有效性及副作用。方法选取2012年7月到2014年6月,恶性胸腔积液患者93例,先行胸腔中心静脉置管穿刺及积液引流后,采用向腔内注射博莱霉素、丝裂霉素、香菇多糖三种药物治疗恶性胸腔积液;B超评价治疗效果;为减轻不良反应,增加患者的耐受度,注射前注入2%利多卡因5 ml。结果博莱霉素组与香菇多糖组有效率分别为84.37%与87.1%,两组间没有显著性差异(P>0.05),丝裂霉素有效率为50%,与博莱霉素组及香菇多糖组有显著差异(P<0.05)。结论香菇多糖与博莱霉素在治疗恶性胸腔积液中有很好的治疗效果,优于丝裂霉素,而且香菇多糖副作用相对较少。
Objective To compare the clinical efficacy and side effect of three different drugs in the treatment of malignant pleural effusion. Methods From July 2012 to June 2014,93 patients with malignant pleural effusion were given central venous catheter drainage,and then injected with bleomycin,mitomycin and mushrooms polysaccharide. The clinical effect was evaluated by B ultrasound. In order to reduce the adverse reaction and increase patients＇ tolerance,all patients were injected with 5 ml of 2% lidocaine. Results The effective rate was 84. 37% in the bleomycin group and 87. 1% in the mushrooms polysaccharide group（ P 〉0. 05）. The effective rate was 50% in the mitomycin group,which showed significant difference with the BLM group and the mushrooms polysaccharide group（ P〈 0. 05）. Conclusion Mushrooms polysaccharide and bleomycin element have a good therapeutic effect in the treatment of malignant pleural effusion of patients,and mushrooms polysaccharide have relatively few side effects.
出处
《临床肺科杂志》
2015年第5期812-815,共4页
Journal of Clinical Pulmonary Medicine
