摘要
目的探讨营养支持联合辛伐他汀对慢性肺心病(CPHD)急性加重期并发呼吸衰竭患者免疫功能和血气指标的影响。方法选择我院2010年4月-2013年5月收治的175例慢性肺心病患者为研究对象,均为急性发作而入院,合并有呼吸衰竭,采用随机数字表法随机分为对照组(88例)和观察组(87例),对照组予以常规治疗和标准饮食,观察组在上述基础上联合营养支持+辛伐他汀,比较两组治疗前后营养功能、免疫功能、血气指标变化。结果观察组治疗后前白蛋白PA(0.37±0.05)g/l、淋巴细胞计数TLC(2.58±0.68)109/l、肌酐身高指数CHI(6.43±0.28)等营养指标明显大于对照组;Ig A免疫指标(3.59±0.71)mg/l,动脉血氧分压Pa O2(77.43±2.58)mm Hg明显高于对照组,动脉血二氧化碳分压Pa CO2(44.09±3.01)mmHg明显低于对照组。结论营养支持联合辛伐他汀可以显著改善CPHD急性发作期合并呼衰患者的营养状况,提高兔疫功能,有利于病人早日康复。
Objective To investigate the effect of simvastatin combined with nutritional support on immune function and blood gas index in the treatment of AECOPD patients complicated with respiratory failure disease. Methods 75 AECOPD patients in our hospital from 2010 April to 2013 May were randomly divided into the control group（ 88 cases） and the observation group（ 87 cases）. The control group was given routine treatment and standard diet,and the observation group was combined nutritional support and simvastatin. Their nutritional function,immune function and blood gas index were compared between the two groups. Results After the treatment,the level of pre-albumin（ PA） was（ 0. 37 ± 0. 05） g / l,the TLC was（ 2. 58 ± 0. 68） 109 / l,and the CHI was（ 6. 43 ± 0. 28） in the observation group,which were all significantly greater than those in the control group. The immune index of Ig A was（ 3. 59 ± 0. 71） mg/l,and Pa O2was（ 77. 43 ± 2. 58） mm Hg in the observation group,which were significantly higher than those in the control group. The level of Pa CO2was（ 44. 09 ± 3. 01） mm Hg,which was significantly lower than that in the control group. Conclusion Nutrition support combined with simvastatin can significantly improve nutritional status and improve immune function.
出处
《临床肺科杂志》
2015年第5期892-894,共3页
Journal of Clinical Pulmonary Medicine
关键词
呼吸衰竭
慢性肺心病
辛伐他汀
营养支持
respiratory failure
chronic pulmonary heart disease
simvastatin
nutritional support
