摘要
目的:探讨三维适形放疗联合内分泌治疗晚期老年前列腺癌疗效以及对患者生活质量的影响。方法:选择我院治疗的晚期老年前列腺癌患者60例,随机分为观察组和对照组,对照组采用内分泌治疗,观察组在对照组基础上联合使用三维适形放疗治疗,观察两组治疗效果。结果:观察组治疗总有效率为60.00%,对照组治疗总有效率为30.00%,组间对比差异有统计学意义(χ2=5.4545;P<0.05)。观察组治疗后前列腺特异性抗原浓度(0.27±0.08),国际前列腺症状评分(10.34±1.05),下降幅度同对照组治疗后比较差异有统计学意义(t=6.5660、8.7053;P<0.05)。观察组治疗后身体功能(1.87±0.64)、情绪功能(1.96±0.53)、角色功能(1.68±0.48)、社会功能(1.41±0.42)、总体生活质量评分(5.52±1.20),上述指标评分均高于对照组,经比较差异有统计学意义(t=3.6473、9.9920、7.3596、5.8496、5.6804;P<0.05)。结论:采用三维适形放疗联合内分泌治疗晚期老年前列腺癌疗效可靠,能够有效改善患者临床症状和体征,提高患者生活质量,值得在临床上大力推广使用。
Objectives： To investigate the clinical effect and influence of three- dimensional conformal radiotherapy combined with endocrine therapy on the living quality of advanced elderly patients with prostate tumors.Methods： 60 advanced elderly patients with prostate cancer in our hospital were chosen and randomly divided into observation group and control group. Control group received the endocrine therapy. Observation group received three- dimensional conformal radiotherapy combined with endocrine therapy. The treatment effect of two groups was ob-served. Results： The total effective rate in treatment group and control group was 60. 00% and 30. 00% respectively,with statistically significant difference（ χ^2= 5. 4545; P〈 0. 05）. Prostate specific antigen density of observation group after treatment was（ 0. 27 ± 0. 08）. The international prostate symptom score was（ 10. 34 ± 1. 05）. Comparing with control group,the difference was statistically significant（ t = 6. 5660,8. 7053; P〈 0. 05）. After treatment,body function of observation group was（ 1. 87 ± 0. 64）; emotional function was（ 1. 96 ± 0. 53）; the role function was（ 1. 68 ± 0. 48）; social function was（ 1. 41 ± 0. 42）; the overall quality of life score was（ 5. 52 ±1. 20）. All the index scores were higher than these of control group,with statistically significant difference（ t =3. 6473,9. 9920,7. 3596,5. 8496,5. 6804; P〈 0. 05）. Conclusion： Three- dimensional conformal radiotherapy combined with endocrine therapy can effectively improve the clinical symptoms and signs of on elderly patients with prostate tumors,and improve their living quality,thusly worthy popularization.
出处
《中国性科学》
2015年第3期18-21,共4页
Chinese Journal of Human Sexuality
关键词
三维适形放疗
内分泌
老年
前列腺癌
生活质量
Three-dimensional conformal radiotherapy
Endocrine therapy
Elderly patients
Prostate tumors
Living quality
