摘要
目的:探讨帕瑞昔布钠对宫颈癌根治术患者术后镇痛的影响。方法:80例行宫颈癌根治术患者,随机将其分为观察组和对照组,各40例。观察组在麻醉诱导后静脉注射帕瑞昔布钠。对照组输注生理盐水。结果:术后6h、12h,观察组咳嗽、安静痛VAS评分低于对照组咳嗽、安静痛VAS评分,差异具有统计学意义(P<0.05)。术毕、术后12h、24h,观察组的IL-6、TNF-α浓度低于对照组IL-6、TNF-α浓度,差异具有统计学意义(P<0.05)。术后12h、24h,观察组IL-8浓度低于对照组IL-8浓度,差异具有统计学意义(P<0.01)。观察组舒芬太尼用量少于对照组舒芬太尼用量,差异具有统计学意义(P<0.01)。术后24h,观察组恶心、嗜睡、呕吐人数少于对照组,下床人数多于对照组,差异具有统计学意义(P<0.01)。结论:帕瑞昔布钠能够减少行宫颈癌根治术患者舒芬太尼的用量,提高镇痛效果,降低炎性因子水平,减少患者不良反应,利于患者术后康复。
Objectives： To study of the pain intervention effect of Parecoxib Sodium on patients with cervical cancer radical operation. Methods： 80 cases of cervical cancer radical operation patients were randomly divided into control group and observation group,40 cases in each group. Control group was given saline infusion. The observation group was given intravenous injection of parecoxib sodium after induction of anesthesia. Results： After the operation 6h and 12 h,the cough and quiet VAS pain scores of the observation group were less than these of the control group,with statistically significant difference（ P〈 0. 05）. After the operation and 12 h and 24 h after the operation,IL- 6 and TNF- α level of the observation group were less than these in the control group,with statistically significant difference（ P〈 0. 05）. 12 h and 24 h after the operation,IL- 8 concentration of the observation group was less than that in the control group,with statistically significant difference（ P〈 0. 01）. The dose of morphine used in the observation group was less than it used in the control group,with statistically significant difference（ P〈 0. 01）. 24 h after the operation the number of nausea,lethargy and vomiting in the observation group were less than these in the control group. The number of patients who got out of bed in the observation group was more than that in the control group,with statistically significant difference（ P〈 0. 01）. Conclusion： Parecoxib Sodium can reduce the dose of morphine in patients with cervical cancer radical operation,enhance the analgesic effect,reduce the level of inflammatory factors,reduce adverse reaction and help the rehabilitation of the patients after operation.
出处
《中国性科学》
2015年第4期8-10,共3页
Chinese Journal of Human Sexuality
基金
浙江省医学会临床科研基金项目(2011ZYC-A73)
