摘要
目的探讨肝硬化患者血清总胆汁酸(TBA)水平对肝硬化诊断的临床意义。方法检测96例肝硬化患者和100例健康对照者血清中TBA水平与ALT水平,分析不同Child-pugh分级与TBA水平的相关性。结果肝硬化组TBA异常率为87.50%,ALT异常率为79.17%,与对照组相比差异有统计学意义(P<0.05)。肝硬化组与正常对照组TBA、ALT测定结果比较差异有统计学意义(P<0.01),不同Child-Pugh分级肝硬化组TBA、ALT比较差异有统计学意义(P<0.05);随级别升高TBA水平显著升高,任意两组TBA比较差异均有统计学意义(P<0.05);ALT的B级组与C级组比较差异无统计学意义(P>0.05)。结论血清总胆汁酸水平对于肝损害具有高敏感性,有利于监测病情、判断预后及治疗,对肝硬化患者具有重要临床意义。
Objective To explore the clinical significance of the serum level of TBA in liver cirrhosis. Methods Detected the serum levels of TBA,ALT of 96 patients with liver cirrhosis at different Child- pugh score and 100 normal controls,analyze the correlation. Results The abnormal rate of TBA was 87. 50% and of ALT was 79. 17% in cirrhosis group,both was significantly higher than those in control group（ P〈0. 05）. There were significant differences of serum level of TBA,ALT between cirrhosis group and control group（ P 0. 01）,the differences in TBA,ALT were significant among groups at different Child- pugh classification（ P〈0. 05）; With progressively increasing of Child- pugh classification of liver cirrhosis,the serum level of TBA were significantly higher. There were statistically differences between any two TBA groups（ P〈0. 05）; There were not statistically differences of ALT between group level B and level C（ P 〉0. 05）. Conclusion Serum level of TBA in patients with liver cirrhosis possesses high sensitivity to liver damage,and has important clinical significance to monitoring of disease,prognosis and treatment.
出处
《中国卫生检验杂志》
CAS
2015年第6期854-855,859,共3页
Chinese Journal of Health Laboratory Technology
