摘要
目的观察胸腺五肽辅助治疗儿童反复呼吸道感染的疗效及对机体免疫功能的影响。方法选取80例反复呼吸道感染患儿,按随机数字表法分为观察组和对照组各40例,对照组给予常规治疗,观察组在此基础上再给予胸腺五肽治疗,随访6个月,观察患儿症状改善情况,检测T细胞亚群和免疫球蛋白水平及不良反应。结果观察组热退时间、咳嗽消失时间、扁桃体肿大消退时间、肺部啰音消失时间明显低于对照组(P<0.01);观察组痊愈率及显效率分别为37.5%(15/40)、45.0%(18/40),对照组痊愈率及显效率分别为10.0%(4/40)和15.0%(6/15),两组痊愈率及有效率比较差异均有统计学意义(P<0.05);观察组治疗后CD3+,CD4+和CD4+/CD8+水平均明显高于治疗前和对照组治疗后,而CD8+水平均明显低于治疗前和治疗后的对照组(P<0.05),两组治疗后IgA、IgG和IgM比较差异均无明显的统计学意义,两组患儿均未发生明显的不良反应。结论胸腺五肽辅助治疗儿童反复呼吸道感染疗效确切、安全性佳,能有效改善患儿免疫功能。
Objective To observe the effect of thymopetidum in the adjunctive therapy on recurrent respiratory tract infection of children and its influence on immune function.Methods Eighty children with recurrent respiratory tract infection who met the inclusion criteria were randomly divided into observation group and control group,40 cases a group.The control group was given conventional treatment,while the observation group received thymopetidum on the basis of conventional treatment.After follow-up for six months,the symptoms were observed,T cells subsets and immunoglobulin were detected,the clinical efficacy was evaluated,and adverse reaction observed.Results The time to defervescence,the disappearing time of coughing and the recovery time of tonsil enlargement,and pulmonary signs between two groups were statistically different（P 〈0.01）;the cure rate and excellence rate of observation group were 37.5%（1 5/40 ）and 45.0% （18/40 ）,and they were significantly higher than 10.0% （4/40 ）and 1 5.0% （6/1 5 ） respectively in control group （all P 〈0.05 ）;CD3 ＋ ,CD4 ＋ and CD4 ＋/CD8 ＋ in observation group were significantly higher than before treatment and after treatment in control group,and CD8 ＋ was significantly lower than before treatment and after treatment in control group （P 〈 0.05 ）,IgA,IgG and IgM in two groups had no significant difference after treatment （P 〉 0.05 ）.No significant adverse reaction was found in two groups.Conclusion Thymopetidum has reliable curative effect and high security on children with recurrent respiratory tract infection and it can effectively improve the immune function.
出处
《临床荟萃》
CAS
2015年第4期390-393,共4页
Clinical Focus
关键词
呼吸道感染
淋巴细胞亚群
胸腺五肽
免疫球蛋白类
respiratory tract infections
lymphocyte subsets
thymopetidum
immunoglobulins
