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D2-40在肝细胞癌组织中的表达及其在淋巴转移中的作用 被引量：2

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摘要 目的探讨D2-40在肝细胞癌组织中的表达及其在淋巴转移中的作用。方法选择35例肝细胞癌患者的手术标本,其中伴淋巴结转移9例、无转移24例。分别取癌组织(肝癌组)、癌边缘组织(癌边缘组)及癌以远(距肿瘤边缘10 cm以上)正常组织(对照组),采用SP免疫组化两步法检测三组D2-40表达,计数微淋巴管密度。结果 D2-40的阳性表达主要分布于癌边缘组织内淋巴管生长密集区。癌边缘组发生转移者D2-40阳性表达率高于无转移者(P<0.05)。肝癌组未见明显微淋巴管,微淋巴管主要分布于癌边缘组及对照组。癌边缘组淋巴结转移者微淋巴管密度高于未转移者(P<0.05)。结论 D2-40可促进肝细胞癌转移,其机制为促进微淋巴管形成。D2-40表达可作为预测肝细胞癌淋巴结转移的标记物。
作者 张西坤 牛洪欣 徐忠法
机构地区 山东省医学科学院附属医院
出处 《山东医药》 CAS 北大核心 2015年第10期74-76,共3页 Shandong Medical Journal
关键词 肝细胞癌 淋巴转移 微淋巴管密度
分类号 R735.7 [医药卫生—肿瘤]
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参考文献18

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二级参考文献47

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山东医药
2015年 第10期

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