摘要
目的：探讨2型糖尿病病人采用改良的中国公式计算肾小球率过滤（c-a GFR）联合尿微量白蛋白与尿肌酐比值（ACR）在诊断糖尿病肾病不同阶段中的临床意义,并做c-a GFR和ACR的相关性分析。方法：根据ACR不同阶段分成4组,A组（正常对照组）,B组（糖尿病正常白蛋白尿组ACR〈30mg/g）,C组（糖尿病肾病微量白蛋白尿组ACR30~300mg/g）,D组（糖尿病肾病大量蛋白尿组ACR〉300mg/g）;应用改良中国MDRD公式c-a GFR（m L/min·1.73m^2）=175×[Hit Pcr]-1.234×年龄-0.179×[女性×0.79]计算GFR,（即c-a GFR,m L/min·1.73m^2）。双变量相关性分析采用Pearson相关分析。结果：与正常对照组相比糖尿病正常白蛋白尿组c-a GFR无明显变化（P〉0.05）,糖尿病肾病微量白蛋白尿组与正常对照组相比c-a GFR降低,有显著变化（P〈0.05）,糖尿病肾病大量蛋白尿组与正常对照组相比c-a GFR降低,有显著变化（P〈0.05）,糖尿病肾病大量白蛋白尿组与糖尿病肾病微量蛋白尿组相比c-a GFR降低,有显著变化（P〈0.05）。与正常对照组相比糖尿病正常白蛋白尿组ACR无明显变化（P〉0.05）,糖尿病肾病微量白蛋白尿组与正常对照组相比ACR增高,有显著变化（P〈0.05）,糖尿病肾病大量蛋白尿组与正常对照组相比ACR增高,有显著变化（P〈0.05）,糖尿病肾病大量白蛋白尿组与糖尿病肾病微量蛋白尿组相比ACR增高,有显著变化（P〈0.05）。c-a GFR随着ACR的增加呈下降趋势,Pearson分析显示二者具有显著负相关性。结论：c-a GFR及ACR可以做为糖尿病肾病诊断的重要监测指标;二者联合检测可以更准确的评估糖尿病患者肾脏功能的情况,对调整糖尿病患者经肾脏代谢的药物剂量及药物的选择都有极为重要的临床指导价值。
Objective： For type 2 diabetic patients,to study the clinical significance of modified Chinese formula to calculate the rate of Glomerular filtration（ c- a GFR） combined urinary microalbumin and urinary creatinine ratio（ ACR） in the diagnosis of different stages of diabetic nephropathy; and to analyze the correlation between c- a GFR and ACR. Methods： 4 groups were divided according to the different stages of ACR,Group A（ normal control group）,Group B（ diabetes normal albuminuria group ACR 30 mg /g）,Group C（ diabetic nephropathy microalbuminuria group ACR30 ~ 300 mg / g）,Group D（ proteinuria of diabetic nephropathy group ACR 300 mg / g）. Modified Chinese c- a GFR MDRD formula（ m L / min·1. 73m^2） = 175 ×[Hit Pcr]- 1. 234 × age- 0. 79 ×[female × 0. 79] was used to calculate GFR,（ that is,c- a GFR,m L / min·1. 73m^2）. Pearson correlation was used to analyze Bivariate correlation. Results： Compared with normal control group,c- a GFR in group B did not change significantly（ P〉0. 05）. C- a GFR in Group C was lower than that in group A significantly（ P 〈0. 05）. C- a GFR in Group D reduced significantly compared with control group（ P 〈0. 05）. c- a GFR in Goup D was lower than that in Croup C significantly（ P 〈0. 05）. There was no significant change of ACR in Group B compared with control group（ P 〉0. 05）. ACR increased significantly in Group C compared with control group（ P 〈0. 05）. ACR increased significantly in group D compared with control group（ P 〈0. 05）. ACR in Group D increased significantly compared with group C（ P 〈0. 05）. c- a GFR was on downward trend alongside the increase of ACR. Pearson analysis showed that there existed significant negative correlation between the two.Conclusions： c- a GFR and ACR can be used as indicators for monitoring diabetic nephropath. Combined detection can much more accurately assess renal function in patients with diabetes,which has important clinical valu to adjust Diabetic Renal metabolism of drug dosages and drug choices.
出处
《黑龙江医药科学》
2015年第2期93-95,共3页
Heilongjiang Medicine and Pharmacy
关键词
2型糖尿病
糖尿病肾病
肾小球滤过滤
尿微量白蛋白与尿肌酐比值
type 2 diabetes mellitus
diabetic nephropathy
glomerular filtration
urinary microalbumin and urinary creatinine ratio
