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贝伐单抗在肺癌中的研究进展 被引量:7

Research Progress of Bevacizumab in Treatment of Lung Cancer
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摘要 肺癌是目前最常见的恶性肿瘤之一,其发病率有逐年增高的趋势,且患者的预后及生存期很差。贝伐单抗于2004-02-26获得美国食品药品监督管理局(FDA)批准,是美国第一个批准上市的抑制肿瘤血管生成的药物,在肺癌的药物治疗中占据重要地位。目前贝伐单抗在肺癌中的研究多从1或2个角度来论述,难以让读者清楚贝伐单抗与肺癌的关系。本文主要从血管内皮生长因子在肿瘤发病机制中的作用、贝伐单抗治疗肺癌的机制、所检测的生物标志物、分期研究、耐药机制及毒副作用等角度较为全面地阐述贝伐单抗在肺癌中的研究进展。 Lung cancer is one of the most common malignant tumor at present,its morbidity tends to increase year by year,and the prognosis and survival of the patients is poor. Bevacizumab,the first anti- tumor angiogenesis drug which was approved on sale by FDA on 26 February 2004, is an important drug for lung cancer treatment. At present, the studies on Bevacizumab in treatment of lung cancer mainly focus on one or two perspectives, thus readers can not fully understand the relationship between Bevacizumab and lung cancer. The research progress of Bevacizumab in treatment of lung cancer is comprehensively discussed in this paper from the perspective of the role of vascular endothelial growth factor in the pathogenesis of cancer,the mechanism of Bevacizumab in treatment of lung cancer,therelated biomarkers,studies on staging,mechanism of drug resistance and adverse effects of Bevacizumab in treatment of lung cancer.
出处 《中国全科医学》 CAS CSCD 北大核心 2015年第9期1002-1005,共4页 Chinese General Practice
基金 国家自然科学基金青年项目(81302934) 浙江省科技厅钱江人才计划(2012R10063)
关键词 肺肿瘤 贝伐单抗 受体 血管内皮生长因子 生物学标记 药理学 抗药性 肿瘤 药物毒性 Lung neoplasms Bevacizumab Receptors vascular endothelial growth factors Biomarkers pharmacological Drug resistance neoplasms Drug toxicity
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  • 1金正均.合并用药中的相加[J].中国药理学报,1980,1:70-73.
  • 2Folkman J. Tumor angiogenesis." therapeutic implications. N Engl J Med, 1971, 285(21): 1182-1186.
  • 3Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin, 2012, 62(1): 10-29.
  • 4Cuaron J, Dunphy M, Rimner A. Role of FDG-PET scans in staging, response assessment, and foUow-up care for non-small cell lung cancer. Front Oncol, 2012, 2: 208.
  • 5Vokes EE, Salgia R, Karrison TG. Evidence-based role ofbevicumab in non- small cell lung cancer. Ann oncol, 2013, 24(1): 6-9.
  • 6Gordon MS, Margolin K, Talpazv M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with ad-canced cancer. J Clin Oncol, 2001, 19(3): 843-850.
  • 7Dy GK, Adjei AA. Angiogenesis inhibitors in lung cancer:a promise fulfilled. Clin Lung Cancer, 2006, ( Suppl 4): S 14S-S 149.
  • 8O'Reilly MS, Boehm T, et al. Endostatin:an endogenous inhibitor of angiogenesis and tumor growth. Cell, 1997, 88(2): 277-285.
  • 9Tan H, Mu G, Zhu W, et al. Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium derived factor make low molecular weight heparin-endostatin and polyethylene glycol-endostatin potential candidates for anti-angiogenesis drug. Biol Pharm bull, 2011, 34(4): 545-550.
  • 10Dhanabal M, Ramchandran R, Waterman MJ, et al. Endostatin induces endothelial cell apoptosis.J Biol Chem, 1999, 274( 17): 1172-1176.

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  • 1SANDLER A, YI J, DAHLBERG S, et al. Treatment outcomes by tumor histology in Eastern Cooperative Group Study E4599 of bevacizumab with paclitaxel/carboplatin for advanced non-small cell lung cancer [J]. J Thorac Oncol, 2010, 5(9): 1416-1423.
  • 2NIHO S, KUNITOH H, NOKIHARA H, et al. Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer [J]. Lung Cancer, 2012, 76(3): 362-367.
  • 3BRAHMER J R, DAHLBERG S E, GRAY R J, et al. Sex differences in outcome with bevacizumab therapy: analysis of patients with advanced-stage non-small cell lung cancer treated with or without bevacizumab in combination with paclitaxel and carboplatin in the Eastern Cooperative Oncology Group Trial 4599 [J]. J Thorac Oncol, 2011, 6(1): 103-108.
  • 4JOHNSON D H, FEHRENBACHER L, NOVOTNY W F, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer [J]. J Clin Oncol, 2004, 22(11): 2184-2191.
  • 5LIU K J, DING L Y, WU H Y. Bevacizumab in combination with anticancer drugs for previously treated advanced non-small cell lung cancer [J]. Tumor Biol, 2015, 36(3): 1323-1327.
  • 6MORO-SIBILOT D, SMIT E, DE CASTRO CARPENO J, et al. Outcomes and resource use of non-small cell lung cancer (NSCLC) patients treated with first-line platinum-based chemotherapy across Europe: FRAME prospective observational study [J]. Lung Cancer, 2015, 88(2): 215-222.
  • 7TAKEDA M, SETO T, HAYASHI H, et al. Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (WJOG 5910L): An open-label, randomized, phase II trial [C]//ASCO Annual Meeting Proceedings. Chicago, USA: Journal of Clinical Oncology, 2015: 8056.
  • 8HATTORI Y, SATOUCHI M, SHIMADA T, et al. A phase 2 study of bevacizumab in combination with carboplatin and paclitaxel in patients with non-squamous non-small-cell lung cancer harboring mutations of epidermal growth factor receptor (EGFR) after failing first-line EGFR-tyrosine kinase inhibitors (HANSHIN Oncology Group 0109) [J]. Lung Cancer, 2015, 87(2): 136-140.
  • 9MASAGO K, FUJIMOTO D, FUJITA S, et al. Response to bevacizumab combination chemotherapy of malignant pleural effusions associated with non-squamous non-small-cell lung cancer [J]. Mol clin oncol, 2015, 3(2): 415-419.
  • 10LIAO B C, SHAO Y Y, CHEN H M, et al. Comparative effectiveness of first-line platinum-based chemotherapy regimens for advanced lung squamous cell carcinoma [J]. Clin Lung Cancer, 2015, 16(2): 137-143.

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