摘要
目的:探讨甘露聚糖肽胶囊对反复呼吸道感染(RRTI)患儿机体免疫功能的影响及其临床疗效。方法:110例RRTI患儿随机分为治疗组(55例)和对照组(55例)。治疗组服用甘露聚糖肽胶囊,对照组口服匹多莫德口服液,所有患者均给予抗感染等对症治疗,观察治疗前后T淋巴细胞亚群、血清免疫球蛋白和临床症状的变化。结果:RRTI患儿经治疗后血清免疫球蛋白Ig G、Ig M、Ig A含量和T淋巴细胞亚群CD3+、CD4+较治疗前明显升高。免疫功能各项指标比较差异均具有统计学意义(P<0.05)。治疗组发热、咳嗽、喘息等临床症状治愈时间和抗生素使用时间较对照组显著缩短(P<0.05),临床疗效无统计学差异(P>0.05)。治疗组患儿随访时间1年内感染发作次数较对照组显著降低(P<0.05)。每次感染发作病情严重程度相当(P>0.05)。结论:甘露聚糖肽胶囊能提升RRTI患儿免疫功能,缩短治疗时间,降低呼吸道感染复发次数。
Objective： To investigate the Mannatide Capsules on recurrent respiratory tract infection（RRTI） influences the immune function in children and its clinical efficacy. Methods： 110 cases of RRTI were randomly divided into treatment group（55 cases） and control group（55 cases）. The treatment group takes Mannatide Capsules, control group oral Pi do Maude oral liquid, all patients were given anti infection such as symptomatic treatment were observed before and after treatment, changes of T lymphocyte subsets, serum immunoglobulin and clinical symptoms. Results： In RRTI group, after treatment, serum immunoglobulin Ig G, Ig M, Ig A content and T lymphocyte subsets and CD3＋, CD4＋ significantly after treatment. The indexes of immune function difference was statistically significant（P〈0.05）. The treatment of fever, cough, wheezing group and other clinical symptoms and cure time and the use of antibiotics in time significantly shorter than the control group（P〈0.05）, no significant difference in clinical efficacy（P〉0.05）. The treatment group received the follow-up time of 1 years of infection episodes decreased significantly compared with the control group（P〈0.05）. Every infection episodes quite severity（P〉0.05）. Conclusion： Mannatide capsule can improve the immune function of children with RRTI, shorten treatment time and reduce the number of recurrent respiratory tract infection.
出处
《中国医药导刊》
2014年第11期1414-1415,共2页
Chinese Journal of Medicinal Guide
关键词
甘露聚糖肽
小儿
反复呼吸道感染
Mannatide
Recurrent Respiratory Tract Infections
Children
