摘要
目的探讨中性粒细胞明胶酶相关脂质运载蛋白检测对妊娠高血压综合征患者早期肾损伤辅助诊断的价值。方法选择2012年2月至2013年7月在本院门诊和住院确诊为妊娠高血压综合征并伴有肾损伤的患者120例设为实验组,按照病情严重程度分为轻度组、中度组和重度组,选择同期健康体检妊娠者40例设为对照组,均进行中性粒细胞明胶酶相关脂质运载蛋白和胱抑素C浓度水平测定。结果与对照组比较,试验各组患者的中性粒细胞明胶酶相关脂质运载蛋白和胱抑素C浓度水平均有显著性提升,差异有统计学意义(P<0.05),且随着患者病情加重,两项指标呈现逐步升高的趋势;试验各组患者的中性粒细胞明胶酶相关脂质运载蛋白和胱抑素C阳性检出率均在85.00%以上,且各组患者两项指标阳性检出率两两比较,均无显著性差异(P>0.05);中性粒细胞明胶酶相关脂质运载蛋白检测结果与以临床诊断结果作为金标准的结果一致性检验Kappa值为0.92。结论中性粒细胞明胶酶相关脂质运载蛋白是辅助诊断妊娠高血压综合征患者的早期肾损伤的一种良好血清指标,且对于患者病情监测也具有一定的临床价值,同胱抑素C一样具有较高的灵敏度,值得临床推广。
Objective To explore the value of the pregnancy-induced hypertension syndrome early renal damage aux-iliary diagnosis by the neutrophil gelatinase-associated lipocalin testing.Methods Choosing 120 cases of the pregnancy-induced hypertension syndrome patients for the experimental group,according to the disease complicated with renal in-jury severity was divided into mild,moderate group and severe group,and 40 cases healthy check-upes for the control group,testing the neutrophil gelatinase-associated lipocalin and Cystatin C,and analyzing the results.Results Com-pared with the control group,there were significantly increased of the neutrophil gelatinase-associated lipocalin and Cys-tatin C the experimental group（P 〈0.05）.The positive rate of the neutrophil gelatinase-associated lipocalin of the pa-tients all were over the 85.00%,and there were no significantly difference between the positive rate of the neutrophil gelatinase-associated lipocalin and Cystatin C （P 〉0.05）.With clinical diagnosis as the gold standard,the Kappa was 0.92.Conclusion There is a good indicators of the neutrophil gelatinase-associated lipocalin for the pregnancy-induced hypertension syndrome early renal damage auxiliary diagnosis and also for condition monitoring which has high sensitiv-ity,Worthy of clinical promotion.
出处
《中国实验诊断学》
2015年第4期593-595,共3页
Chinese Journal of Laboratory Diagnosis
