摘要
目的观察丙酸氟替卡松吸入气雾剂用于儿童肺炎支原体感染所致的慢性咳嗽的临床疗效。方法 168例支原体感染所致的慢性咳嗽患儿,随机分为治疗组和对照组,各84例。治疗组给予阿奇霉素口服治疗4个疗程,开始1周配合雾化吸入布地奈德混悬液和硫酸特布他林雾化液,咳嗽明显缓解后,序贯给予丙酸氟替卡松吸入气雾剂治疗,疗程3个月;对照组给予阿奇霉素口服治疗4个疗程结合对症药物治疗,观察两组患儿临床疗效、咳嗽缓解时间、3个月咳嗽加重就诊次数、3个月治疗费用、治疗后随访3个月复发例数。结果治疗组总有效率95.24%,对照组总有效率69.05%,两组比较,差异有统计学意义(P<0.01);两组在治疗过程中均未见明显不良反应,治疗组咳嗽缓解时间明显短于对照组(P<0.05);治疗组3个月治疗费用及3个月平均就诊次数明显低于对照组(P<0.05);对照组3个月咳嗽复发例数明显多于治疗组(P<0.01)。结论丙酸氟替卡松吸入气雾剂序贯治疗儿童因支原体感染所致的慢性咳嗽安全有效,可有效改善患儿临床症状、体征,避免咳嗽反复,值得临床推广应用。
Objective To observe the clinical effect of fluticasone propionate inhalation aerosol in the treatment of chronic cough caused by children mycoplasma pneumoniae infection. Methods A total of 168 children with chronic cough caused by mycoplasma pneumoniae infection were randomly divided into treatment group and control group, with 84 cases in each group. The treatment group received oral administration of azithromycin for 4 treatment courses. Budesonide suspension and terbutaline hemisulfate atomized liquid through aerosol inhalation was taken in the first week, and sequential aerosol inhalation of fluticasone propionate after obvious relief of cough for 3 months as a treatment course. The control group was given azithromycin by oral administration combined with symptomatic treatment drugs for 4 treatment courses. Observations were made on clinical effects, cough relief time, exacerbation treatment time in 3 months, medical cost in 3 months, and relapse cases in 3 months of the two groups. Results The treatment group had the total effective rate as 95.24%, and that in the control group was 69.05%. The difference between the two groups had statistical significance （P〈0.01）.Both groups had no obvious adverse reactions during treatment. The treatment group had shorter cough relief time than the control group （P〈0.05）, its medical cost and average treatment time were all less than the control group （P〈0.05）, and the control group had obviously more relapse cases in 3 months than the treatment group （P〈0.01）. Conclusion Sequential therapy by fluticasone propionate inhalation aerosol is safe and effective in the treatment of chronic cough caused by children mycoplasma pneumoniae infection. This method can effectively improve clinical symptoms and signs, and avoid relapse cough, and it is worthy of clinical promotion and application.
出处
《中国现代药物应用》
2015年第10期5-7,共3页
Chinese Journal of Modern Drug Application
关键词
丙酸氟替卡松吸入气雾剂
儿童
肺炎支原体感染
慢性咳嗽
Fluticasone propionate inhalation aerosol
Children
Mycoplasma pneumoniae infection
Chronic cough
