摘要
中药多糖的分子修饰是运用物理、化学、生物等方法对其主链或侧链的某些特殊结构或功能基团进行修饰,使多糖的某些物理化学性质和空间结构发生改变,以增强其生物活性。其中物理方法包括超声波方法和辐照技术;化学方法主要有硫酸化、磷酸化、乙酰化、羧甲基化、烷基化、磺酰化和硒化等方法;生物方法也称酶法,分为酶降解法和酶合成法。经过分子修饰后中药多糖的物化性质和空间结构发生一定改变,使得多糖的免疫调节、抗病毒、抗肿瘤、抗氧化等药理活性明显增强。就近年来中药多糖的主要分子修饰方法及分子修饰后多糖的药理活性研究进展进行综述。
Molecular modification of Chinese materia medica polysaccharides（CMMP） is considered as the technology of modification on some special structure or functional group in the main chain or the side chain of polysaccharides on the purpose of changing certain physicochemical properties and the spatial structure of polysaccharides by using physical, chemical and biological methods which can enhance the biological activity. Physical methods mainly include ultrasonic method and irradiation technology. Chemical methods refer to sulfation, phosphorylation, acetylation, carboxymethylation, alkylation, sulfonylation, selenylation, and so on. Biological method is also called the enzymatic modification containing enzyme degradation and enzymatic synthesis. In recent years, it has been shown that the physicochemical properties and spatial structure of CMMP could be changed after modification, which could make their immunopharmacology activity, such as immune adjustment, antivirus, antitumor, and antioxidant, enhanced obviously. The main modification methods of CMMP and the related pharmacological activity of its products after modification are summarized in this paper.
出处
《中草药》
CAS
CSCD
北大核心
2015年第7期1074-1080,共7页
Chinese Traditional and Herbal Drugs
基金
陕西省科技攻关项目(2013K01-61-01)
西北农林科技大学2013年大学生创新创业训练计划校重点项目(2201210712048)
关键词
中药
多糖
分子修饰
免疫药理学
酶法
Chinese materia medica
polysaccharides
molecular modification
pharmacological activity
enzymatic method
