摘要
目的观察口腔黏膜下纤维性变（OSF）并存白斑（OLK）患者的临床表现以及病理特征，探讨其上皮异常增生程度与纤维性变严重程度的相关性。方法整理74例OSF并存OLK患者的临床病理资料并进行分析。结果74例OSF并存OLK患者多见于中青年男性，均有咀嚼槟榔史，以20～49岁年龄段发病率较高，临床上同时具有OSF、OLK的临床症状和体征。病理表现为上皮细胞间隙增宽；基底膜增厚、不规则；胶原纤维水肿，变性。结论OSF并存OLK患者的上皮异常增生程度与纤维性变严重程度无显著相关性；OSF并存OLK并非两种疾病的单纯叠加，而具有其特征性的表现。
Objective The objective of this study is to observe the clinical and pathological characteristics of oral submucous fibrosis（OSF） coexisting with oral leukoplakia（OLK） to analyze the relationship between the degree of epithelial hyperplasia and the severity of fibrosis. Methods The clinical and pathological data of 74 patients with OSF coexisting with OLK were collected and reviewed. Results Seventy-four patients with OSF coexisting with OLK were mainly young and middle-aged male patients. All had the habit of chewing betel quid, and all exhibited symptoms of OSF and OLK, but higher prevalence is observed in age range of 20 to 49. Pathological features include widened epithelial cell gap, thickened basement membrane, and degenerated collagen fibers. Conclusion No relationship was found between the degree of epithelial hyperplasia and the severity of fibrosis in patients with OSF coexisting with OLK. OSF coexisting with OLK is not simply a combination of two diseases; rather, the combination of which has peculiar features.
出处
《国际口腔医学杂志》
CAS
北大核心
2015年第3期273-275,共3页
International Journal of Stomatology
