摘要
目的:观察新疆昆仑雪菊提取物对糖尿病小鼠血糖的影响,初步探讨其可能的作用机理。方法:采用高糖高脂饲料喂养联合小剂量链脲佐菌素(STZ)腹腔注射诱导糖尿病小鼠模型,将成模小鼠按血糖均衡随机分为模型组、新疆昆仑雪菊提取物低(2 g·kg-1)、中(4 g·kg-1)、高(8 g·kg-1)剂量组和二甲双胍(0.16 g·kg-1)组,取同批次健康小鼠作为空白组。对血糖、C肽、糖化血红蛋白(Hb A1c)、IRI和ISI等指标进行观察分析。结果:干预4周后,与模型组比较,新疆昆仑雪菊提取物中、高剂量组可降低糖尿病小鼠的血糖和糖化血红蛋白值(P<0.05),提取物三个剂量组都可提高血清的C肽水平和ISI值(P<0.01),提取物高剂量组可降低IRI值(P<0.01)。结论:新疆昆仑雪菊提取物可能通过增加胰岛素分泌,减轻胰岛素抵抗以及恢复胰岛β细胞功能来发挥降血糖作用。
Objective：To observe the effects of extracts from Xinjiang Kunlun Coreopsis tinctoria lfowers on blood glucose in diabetic mice and investigate the mechanism preliminarily. Methods：Diabetic mice were induced by high-fat and high-sugar diet and peritoneal injection low dose of streptozotocin （STZ）, which were randomly divided into model group, Xinjiang Kunlun Coreopsis tinctoria lfowers extracts treatment groups （with the doses of 2, 4 and 8 g·kg^-1） and the metformin positive control group （0.16 g·kg^-1）. The normal mice from the same batch were used as the normal control group. The indexes of blood glucose, C-peptide, HbA1c, ISI, IRI were observed. Results： The extracts of medium and high dose treatment group can reduce blood glucose and HbA1c （P〈0.05）. All extracts treatment groups can increase serum C-peptide levels and ISI （P〈0.01）. The extracts of high dose treatment group can decrease IRI （P〈0.01） in diabetic mice for 4 weeks treatment compared with model group. Conclusion：The extracts of Xinjiang Kunlun Coreopsis tinctoria flowers can significantly reduce blood glucose by increasing insulin secretion, reducing insulin resistance and the recovering pancreaticβ-cellfunction probably in diabetic mice.
出处
《中国药物应用与监测》
CAS
2015年第2期82-84,132,共4页
Chinese Journal of Drug Application and Monitoring
基金
NSFC-新疆联合基金重点项目(U1303223)
关键词
昆仑雪菊
糖尿病小鼠
血糖
Coreopsis tinctoria lfowers
Diabetic mice
Blood glucose
