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骨原发上皮样血管肉瘤临床病理学分析 被引量:2

A clinical and pathological analysis of primary epithelioid angiosarcoma in bone
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摘要 目的探讨骨原发上皮样血管肉瘤(PEAB)的临床病理特点。方法报道1例骨原发上皮样血管肉瘤临床资料、组织学及免疫组化染色结果及随访结果。结果该例骨原发上皮样血管肉瘤的临床症状为局部疼痛,查体发现局部压痛,镜下示上皮样肿瘤细胞排列成假腺样、乳头状,可见原始血管结构形成。免疫组化显示瘤细胞高表达CD31、CKpan、Vimentin,并表达CD34,而EMA、SMA、S-100、Myogenin及HMB45等均阴性。结论骨的原发上皮样血管肉瘤罕见,其组织结构极易被误诊为转移癌,诊断需结合临床及影像学资料,对组织病理学的详细观察及免疫组化染色的协助,对于正确诊断和鉴别诊断有重要意义。 Objective To investigate the clinicopathological characteristics,diagnosis and differential diagnosis,treatment and prognosis of primary epithelioid angiosarcoma in bone PEAB.Methods One case of PEAB was retrospectively reviewed on the clinical data,his-tological and immunohistochemical features,the follow-up,and the related literature.Results The symptom of the case was localized pain.Physical examination results showed that there was local tenderness.Histologically,PEAB was comprised of the epithelioid-like cells arranged in pseudoglandular or papillary patterns.Structure of primitive vascular can be seen in some areas.Immunohistochemical-ly,the tumor cells were stained positive for CD31,CK,vimentin and CD34,negative for SMA,S-100,EMA,Myogenin and HMB45.Con-clusions PEAB is very rare.Because of its histopathological character,it is likely to be misdiagnosed as metastatic carcinoma.An ac-curate diagnosis is based on clinical manifestations,imaging,histopathological test and immunohistochemical staining.
出处 《安徽医药》 CAS 2015年第4期706-709,共4页 Anhui Medical and Pharmaceutical Journal
关键词 骨肿瘤 血管肉瘤 上皮样血管肉瘤 免疫组化 bone neoplasms angiosarcoma epithelioid angiosarcoma immunohistochemical
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