摘要
目的：探讨不同严重程度溃疡性结肠炎患者血清TNF-α、IL-6及IL-8的表达及意义。方法：选择2011年1月~2014年7月我院收治的溃疡性结肠炎患者47例,根据严重程度将患者分为轻度组、中度组和重度组。另选取同期在我院接受健康体检的志愿者80例作为对照组。采用酶联免疫吸附试验（ELISA）检测各组患者血清TNF-α、IL-6及IL-8的水平。结果：溃疡性结肠炎患者血清TNF-α、IL-6及IL-8水平高于对照组,差异有统计学意义（P〈0.05）;不同严重程度溃疡性结肠炎患者的TNF-α、IL-6及IL-8水平呈显著差异（P〈0.05）。结论：检测溃疡性结肠炎患者血清TNF-α、IL-6及IL-8的水平变化有利于预测病情进展。
Objective： To investigate the expressions and significance of TNF-α, IL-6 and IL-8 in patients with ulcerative colitis （UC） at different degrees. Methods： 47 patients with ulcerative colitis at different degrees who were treated in our hospital from January 2011 to July 2014 were selected and divided into the slight group, the medium group and the severe group on the basis of clinical stages. And another 80 healthy subjects were included as the control group. The levels of TNF-α, IL-6 and 1L-8 in each group were detected by the ELISA and the results were compared. Results： Serum TNF-α, IL-6 and IL-8 levels in UC patients were higher than those of the con- trol group, and the differences were statistically significant （P〈0.05）. There were statistically significant differences about the levels of TNF-α, IL-6 and IL-8 in patients with ulcerative colitis at different degrees （P〈0.05）. Concision： Detection of serum TNF-α, IL-6 and IL-8 levels can effectively assess the disease progression of UC and provide references for clinical treatment.
出处
《现代生物医学进展》
CAS
2015年第14期2641-2644,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金青年科学基金项目(81301239)
