摘要
[目的]探讨超声造影时间—强度曲线(TIC)在评估宫颈癌新辅助化疗疗效中的价值。[方法 ]对40例行新辅助化疗宫颈癌患者于化疗前和化疗2个疗程后采用超声造影和磁共振成像(magnetic resonance imaging,MRI)检查测量肿物最大径,以病理结果为金标准比较两种影像学方法测量的精确性。观察造影剂灌注情况,应用时间—强度曲线分析病变造影剂的到达时间(AT)、达峰时间(TTP)以及峰值强度(PI),比较化疗前后各参数的变化。[结果]1超声造影与MRI测量精确性未见明显差异(P>0.05)。2化疗有效组32例患者肿物明显缩小,TIC显示TTP较化疗前明显延长(P<0.05),PI下降(P<0.05);化疗无效组8例患者肿物缩小不明显,TTP与化疗前比较未见明显变化(P>0.05),PI有所增高,但无统计学差异(P>0.05)。两组患者的AT均较化疗前延长,但无统计学差异(P>0.05)。[结论]超声造影可作为肿物测量方法之一,时间—强度曲线参数可客观反映化疗前后宫颈肿物的血流灌注变化情况,有助于新辅助化疗效评估。
[Purpose] To investigate the value of time-intensity curves（TIC） of contrast-enhanced ultrasound（CEUS） in assessing the efficacy of neoadjuvant chemotherapy（NACT） for cervical cancer. [ Methods ] CEUS and magnetic resonance imaging （MRI） were performed before and after two courses of NACT in 40 patients with cervical cancer. Maximum diameters of the tumors were mea- sured ,and data obtained by both imaging methods were compared with pathological result as the gold standard. The accuracy of CEUS and MRI was compared. The perfusion mode of the lesions was observed, and the time -intensity curve （TIC） to get arriving time （AT）, time to pick （TYP） and peak intensity（PI） of contrast agent were analyzed. The difference of TIC parameters before and af- ter NACT was compared. [ Results ] ① No significant difference was found between the measure- ment results of two imaging methods（P〉0.05）. ② There are 32 cases with response to chemothera- py,which volume dramatically decreased, TTP of lesions dramatically prolonged （P〈0.05）, PI de- creased （P 〈0.05） compared with before chemotherapy. Eight cases without response to chemotherapy,which volume did not change significantly,TFP of lesions did not change signifi- cantly （P〉0.05）, PI increased with no significant difference（P〉0.05） after chemotherapy; while AT prolonged compared with before NACT,but no significantly difference （P〉0.05）. [Conclusion] CEUS can be used as a method to measure the lesion of cervical cancer,TIC parameters can ob- jectively reflect the perfusion mode changes of the lesion before and after NACT,which benefit for assesing the response of NACT.
出处
《中国肿瘤》
CAS
2015年第5期435-438,共4页
China Cancer
关键词
超声造影
时间—强度曲线
宫颈肿瘤
新辅助化疗
contrast-enhanced ultrasound
time-intensity
cervical cancer
neoadjuvant chemotherapy
