摘要
目的探讨农村维吾尔族妇女宫颈癌的筛查方法,以提高宫颈癌早诊早治率,降低死亡率。方法于2013年5-11月在新疆和田墨玉县进行宫颈筛查研究,对年龄21~60岁的已婚妇女6 000例进行care HPV（德国QIANEN公司）及国产液基细胞学检查（泰普生物科学有限公司）的检测,将care HPV阳性或TCT≥ASC-US的女性再次召回行阴道镜检查及宫颈活检。结果 （1）病理结果中慢性宫颈炎442例,CINⅠ47例,CINⅡ48例,CINⅢ53例,宫颈癌11例（包括9例宫颈鳞癌及2例宫颈腺癌）,病理结果中有1例宫颈结核。宫颈上皮内瘤变Ⅰ~Ⅲ级148例,检出率为2.47%,宫颈癌11例,检出率为0.18%。（2）用care HPV法检测出的HPV阳性人数为505例,HPV感染率为8.42%,TCT结果中阳性人数271例,HPV感染率为4.52%;在148例宫颈癌前病变中HPV感染率为97.30%,在宫颈癌病例中HPV感染率为100%。（3）年龄〉45岁妇女HPV感染率高于≤45岁者（χ2=15.835,P〈0.001）;〈30岁者CIN2＋宫颈病变发生率较低,〉30岁者宫颈病变发生率较高,差异具有统计学意义（χ2=5.534,P=0.019）。（4）女性的早诊率为98.21%（110/112）,早治率为75.0%（84/112）。结论 care HPV和国产液基细胞学检查可以用于宫颈癌的筛查,筛查年龄应该从30岁开始,〉45岁的妇女加强HPV检测,应该加强新疆农村地区宫颈癌的宣传工作。
Objective To explore the screening method for Uyghur women＆#39;s cervical cancer for early diagno-sis and therapy and mortality reduction in rural areas in Xinjiang.Methods The cervical cancer screening research was conducted on Hotan Karakax County in Xinjiang during May to November,2013.Women aged 21-60 accepted careHPV test （QIAGEN Corporation）and domestic Thinprep test provided by Trip-lex International Biosciences （China）Co.LTD.Colposcopy and cervical biopsy was performed to women with positive result of careHPV and TCT result of ≥ASC-US.Results （1）Pathological result showed 442 chronic cervicitis,47 cases of CINⅠ,48 cases of CINⅡand 53 cases of CINⅢ.The result also showed 9 cervical squamous cancer and 2 glandular cancer,1 of cervical tuberculosis.148 cases of cervical intraepi-thelial neoplasia were found out in total,with the relevance ratio of 2.47%;11 cases of cervical cancer with the relevance ratio of 0.18%.（2）HPV infection rate was 8.42%（505/6000）and TCT positive rate was 4.52%.HPV infection rate was 97.30 in 148 CIN patients and 100.00% in cervical cancer patients.（3）＆amp;nbsp;HPV positive rate was higher in women older than 45 compared to women younger than 45 and the differ-ence has statistical differences （χ2 =15.835,P 〈0.001）.Cervical lesion incidence was higher in women of 30 years above than women under 30 years （χ2 =5.534,P =0.019）.（4）Uyghur women′s rate of early di-agnosis in this study was 98.21%（110/112）,and rate of early therapy was 75.0%（84/112）.Conclusion CareHPV and domestic Thinprep test were suitable for Xinjiang cervical cancer screening.Screen should start at women aged 30 and HPV test should be supplemented for women older than 45.Knowledge about cervical cancer should be publicized and promoted for women in Xinjiang rural area.
出处
《新疆医科大学学报》
CAS
2015年第4期400-404,共5页
Journal of Xinjiang Medical University
基金
国家自然科学基金(81160247)
关键词
维吾尔族
宫颈癌
筛查
分析
Uyghur
cervical cancer
screen
analysis
