摘要
目的：观察臭氧水治疗外阴上皮内非瘤样病变的临床疗效。方法选择2010年1月~2013年10月我院妇科门诊收治的外阴上皮内非瘤样病变患者120例[其中鳞状上皮增生（SH）61例、硬化性苔癣/硬化性苔癣合并鳞状上皮增生（LS/LSCSH）59例]，分为臭氧水治疗组90例和药物治疗组（对照组）30例，观察比较两组治疗3个月、6个月有效率及两组复发率和随访情况。结果治疗3个月、6个月臭氧水治疗组每种病理类型有效率及总有效率均明显高于对照组，差异有统计学意义（P〈0.05）；臭氧水治疗SH优于治疗LS/LSCSH（P〈0.05）；臭氧水治疗组每种病理类型复发率及总复发率均低于对照组，差异有统计学意义（P〈0.05）。臭氧水治疗组SH复发率与LS/LSCSH比较，差异无统计学意义（P〉0.05）。所有患者臭氧水治疗中及治疗后未见不良事件发生。结论臭氧水治疗SH和LS/LSCSH优于传统药物，为外阴上皮内非瘤样病变的治疗开创了一种新的选择，值得临床推广应用。
Objective To observe the clinical efficacy of ozone water in treatment of nonneoplastic epithelial disorders of vulva（NEDV）. Methods From January 2010 to October 2013, a total of 120 patients with NEDV admitted to depart-ment of gynecology of the Fifth Affiliated Hospital of Xinjiang Medical University [61 cases of squamous hyperplasia （SH）, while 59 cases of lichen sclerosus/lichen sclerosus complexed with squamous hyperplasia（LS/LSCSH）] were divided randomly into ozone water treatment group （n=90） and drug treatment group （control group, n=30）. Effects of two groups in three months and in six months of treatment and relapse rates and follow-up cases of two groups were compared and observed. Results Effect of each pathological type and the total effective rate of ozone water treatment group in three months and in six months of treatment all were significantly higher than those of control group, the difference was sig-nificant （P〈0.05）. Ozone water treating SH was superior than treating LS/LSCSH （P〈0.05）. Recurrence rate of each pathological type of and the overall recurrence rate of ozone water treatment group were lower than those of the control group, the difference was significant （P〈0.05）. There were no significant differences between SH and LS/LSCSH in recur-rence rate of ozone water treatment group （P〉0.05）. No adverse events were occurred in all patients treated by ozone water. Conclusion Ozone water that is superior to traditional medicines, can effectively treat SH and LS/LSCSH, be-comes a new treatment for NEDV, worthly clinical application.
出处
《中国现代医生》
2015年第10期27-29,32,共4页
China Modern Doctor
关键词
臭氧水
外阴上皮内非瘤样病变
临床疗效
Ozone water
Nonneoplastic epithelial disorders of vulva
Clinical efficacy
