摘要
目的 评价雾化吸入重组人干扰素α1b对重症手足口病(神经系统受累期)患儿的疗效和安全性,为儿科合理用药提供科学依据.方法 采用随机、对照、多中心的设计方法,将3家医院重症手足口病患儿分为2组.对照组采用常规对症治疗,治疗组在此基础上雾化吸入重组人干扰素α1b注射液30 μg/次,2次/d,疗程5~7 d.并采用SPSS 17.0软件进行分析,比较2组患儿疗效.结果 2013年5至11月共66例患儿入组,与对照组比较,雾化吸入重组人干扰素α1b可显著缩短重症手足口病(神经受累期)患儿热程[治疗组(1.9±1.1)d,对照组(2.7±1.2)d,P<0.05]、恢复进食时间[治疗组(3.9±1.4)d,对照组(4.9±1.6)d,P <0.05]和中枢神经系统症状持续时间[治疗组(2.6±1.1)d,对照组(3.2±1.0)d,P<0.05],明显缓解易惊[治疗组(2.4±1.0)d,对照组(3.2±0.9)d,P<0.05]和肢体抖动[治疗组(2.0±1.1)d,对照组(2.9±1.2)d,P<0.05]的持续时间.对治疗组用药期间生命体征、血常规、血生化的观察和检查均未见不良反应.结论 雾化吸入人重组干扰素α1b可用于治疗小儿手足口病,能显著改善重症手足口病早期患儿的神经系统表现和其他临床表现,安全性良好.
Objective To evaluate the efficacy and safety of nebulized recombinant human interferon α1b (IFN-α1b) for severe hand-foot-mouth disease (HFMD)children with central nervous system complications (CNSC).Methods This was a multi-center,prospective,cohort study.Severe HFMD children with CNSC from 3 hospitals were assigned to the control group with conventional therapy,and therapeutic group based on convetional therapy with nebulization of recombinant human IFN-α1 b,30 μg twice each day,for 5-7 days.The curative effect between 2 groups was compared by using SPSS 17.0 software.Results Sixty-six cases were enrolled from May to November 2013.Compared with conventional tberapy,the treatment of nebulized IFN-α1 b could significantly reduce the duration of fever[treatment group (1.9 ± 1.1) d vs control group (2.7 ± 1.2) d,P 〈 0.05],the recovery time of food intake [treatment group (3.9 ± 1.4) d vs control group (4.9 ± 1.6) d,P 〈 0.05] and the duration of the central nervous system syndrome [(2.6 ± 1.1) d vs (3.2 ± 1.0) d,P 〈 0.05],especially shorten the duration of convulsion [treatment group (2.4 ± 1.0) d vs control group (3.2 ± 0.9) d,P 〈 0.05] and myoclonic jerk [(2.0 ± 1.1) vs (2.9 ± 1.2) d,P 〈 0.05].Vital signs,routine hematological and biochemical parameters were monitored and no adverse effect was observed during the treatment.Conclusion Nebulization of human recombinant IFN-α1 b can significantly and safely alleviate early clinical syndrome of severe HFMD children.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2015年第8期627-630,共4页
Chinese Journal of Applied Clinical Pediatrics
基金
新发突发传染病研究北京市重点实验室开放课题(2014XFTF02)
关键词
雾化吸入
手足口病
重组人干扰素Α1B
神经系统受累期
Nebulization
Hand - foot - mouth disease
Human recombinant interferon α1b
Nervous system complications