摘要
目的：探讨绝经后2型糖尿病患者雌激素、空腹胰岛素（FINS）、空腹血糖（FPG）、糖化血红蛋白（HbA1 c）、血脂与颈动脉粥样硬化的关系及临床意义。方法选择绝经后2型糖尿病患者63例，分别进行颈动脉内-中膜厚度（IMT）检测，根据血管狭窄程度，依次分为IMT正常组（A组）、IMT增厚组（B组）、斑块组（C组），同时以15例健康体检者作为对照组（D组）。分别检测各组血浆总胆固醇（TC ）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、FINS、FPG、HbA1c、卵泡刺激素（FSH）、雌二醇（E2）等。结果C组FINS、IR、HbA1c、TC、LDL-C较A组增高（t＝16．83、14．44、2．50、2．38、2．42，P＜0．01或P＜0．05），E2、HDL-C下降（t＝7．32、5．51，均P＜0．01）；D组FINS、HbA1c、TC、LDL-C、FSH、IR均较C组降低（t＝19．74、36.44、8．64、7．95、27．13、6．71，均P＜0．01），HDL-C、E2升高（t＝11．34、8．72，均P＜0．01）。经过Pearson′s相关分析显示，E2与FINS、IR、TC、LDL-C 呈负相关（P＜0．01或P＜0．05），与HDL-C 呈正相关（P＜0．05）。Logistic回归分析显示，IMT与FINS、IR、HbA1c、LDL-C呈正相关（OR值＝2．94、72．63、27．30、98．18，均P＜0.01），而与E2水平呈负相关（OR值＝2．94，P＜0．01）。结论在绝经后2型糖尿病患者中，雌激素是防止颈动脉粥样硬化的保护性因素。
Objective To observe the correlation of estrogen,fasting insulin（FINS）,fasting plasma glucose （FPG）,glycosylated hemoglobin（HbA1c）,blood lipids and carotid arteries -membrane thickening（IMT）in the postmenopausal women with type 2 diabetes.Methods 63 postmenopausal women with type 2 diabetes were divided into normal IMT group（group A）,IMT thickening group（group B）,plaque group（group C）according to the vascular ultrasound carotid artery intima thickness,at the same time 15 cases of healthy physical examination as control group （group D）.All of the groups were detected the plasma total cholesterol（TC）,high-density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol（LDL-C）,fasting insulin（FINS）,fasting plasma glucose（FPG）,gly-cosylated hemoglobin（HbA1c）,follicle-stimulating hormone（FSH）,estradiol（E2）.Results Compared with group A,the levels of FINS,IR,HbA1c,TC,LDL-C in group C was higher（t=16.83,14.44,2.50,2.38,2.42,all P〈0.01 or P〈0.05）,however,the results of E2,HDL-C was decreased（t=7.32,5.51,all P〈0.01）.The levels of FINS,HbA1c,TC,LDL-C,FSH,IR in group D was lower than those of group C（t=19.74,36.44,8.64,7.95, 27.13,6.71,all P〈0.01）,On the contrast,the levels of HDL-C,E2 were elevated（t=11.34,8.72,all P〈0.01）. The Pearson＇s correlation analysis showed that E2 had negative correlation with FINS,IR,TC,LDL-C （P〈0.01 or P〈0.05）.E2 had positive correlation with HDL-C（P〈0.05）.Logistic regression analysis showed that IMT and FINS,IR,HbA1c,LDL-C were positively correlated（OR=2.94,72.63,27.30,98.18,all P〈0.01）,while nega-tively correlated with E2 levels（OR=2.94,P〈0.01）.Conclusion The increased level of estrogen was a protective factor of carotid artery atherosclerosis in postmenopausal women with type 2 diabetes.
出处
《中国基层医药》
CAS
2015年第7期961-963,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省丽水市科技计划项目（2012JYZB94）
