摘要
目的：比较不同剂量瑞舒伐他汀钙治疗冠心病合并高脂血症的临床治疗效果。方法选择100例冠心病合并高脂血症患者，按随着数字表法分为三组，A组患者给予瑞舒伐他汀钙5 mg／d治疗，B组给予10 mg／d治疗，C组给予20 mg／d治疗，4周为1个疗程，连续治疗3个疗程。比较三组疗效及治疗前后血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）及低密度脂蛋白（LDL-C）水平，同时记录三组不良反应发生情况。结果 C组冠心病治疗总有效率为87．9％，对高脂血症治疗总有效率为93．9％，明显高于A组及B组（χ2＝6．54，P＜0．05）；三组治疗后血清TC、TG、HDL-C及HDL-C水平较治疗前明显改善，且C组较另外两组改善明显，差异均有统计学意义（F＝5．45，P＜0．05）；三组治疗过程中均无明显不良反应。结论大剂量瑞舒伐他汀钙治疗冠心病合并高脂血症的疗效显著，可有效调节血脂水平，且无明显不良反应，安全性高。
Objective To investigate the effect of different doses of rosuvastatin Calcium in the treatment of coronary heart disease complicated with hyperlipemia and its effect on blood lipid level.Methods 100 patients with coronary heart disease complicated with hyperlipemia were randomly divided into the three groups according to the number table methods,the patients in group A received rosuvastatin Calcium 5mg/d,group B was given 10mg/d, group C was given 20mg/d.A treatment course was 4 weeks,and continuous treatment lasted 3 courses.The effects after treatment and serum TC,TG,LDL-C and HDL-C levels before and after treatment of the three groups were compared,and the occurrence of adverse reactions in the three groups of patients was recorded.Results The effective rate of C group in the treatment of coronary heart disease was 87.9%,the effective rate in the treatment of hyperlipi-demia was 93.9%,which were significantly higher than those in group A and group B （χ2 =6.54,P〈0.05 ）;The serum TC,TG,HDL-C and HDL-C levels of three groups after treatment were significantly improved compared with before treatment,and which in C group were improved better than the other two groups（F=5.45,P〈0.05）;There was no significant adverse reactions in the three groups during treatment.Conclusion Large dose rosuvastatin Calci-um has a significant therapeutic effect in treatment of coronary heart disease complicated with hyperlipemia,which can effectively regulate blood lipid levels,with no obvious adverse reaction and high security,which is worthy of clinical application.
出处
《中国基层医药》
CAS
2015年第7期980-982,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
冠状动脉疾病
血脂异常
瑞舒伐他汀钙
Coronary Artery Disease
Dyslipidemias
Rosuvastatin calcium
