摘要
目的：探讨脑膜转移瘤（MC）的MRI特征，及其瘤周水肿与血管内皮生长因子（VEGF）表达的相关关系。方法采用1．5 T磁共振仪平扫加增强观察48例MC 的MRI表现，对手术切除的瘤组织行VEGF免疫组化测定。结果48例MC患者的MRI特征表现为3型，瘤组织VEGF表达越强，瘤周水肿越重（χ2＝33．34，P＜0．01）。结论 MC的临床诊断中，MRI扫描不可或缺；其VEGF的表达和瘤周水肿产生呈正相关关系。
Objective To discuss the MRI feature of meningeal metastasis and correlation of peritumoral brain edema and vascular endothelial growth factor（VEGF）expression.Methods 48 patients with meningeal metas-tasis were observed with plain and enhanced 1 .5 T magnetic resonance imaging scans,surgical removal of the tumor tissues was measured with VEGF immunohistochemistry.Results The patients with MC showed three types MRI fea-ture.The more vascular endothelial growth factor of the tumor tissues expressed,the more peritumoral brain edema （χ2 =33.34,P〈0.01 ）.Conclusion MRI scanning is necessary for clinical diagnosis in MC.There are positive correlation between the expression of vascular endothelial growth factor of the tumor tissues and peritumoral brain edema（P〈0.01）.
出处
《中国基层医药》
CAS
2015年第7期1009-1011,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑膜肿瘤
内皮生长因子
瘤周水肿
Meningeal metastasis
Vascular endothelial growth factor
Peritumoral brain edema
