甲状腺功能异常与稽留流产的相关性研究被引量：14

Exploration of the Relationship between Thyroid Dysfunction and Missed Abortion

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摘要目的:探讨甲状腺功能异常与稽留流产的相关性。方法:选取妊娠12周内的95例稽留流产患者为研究对象(观察组),并选择同期正常妊娠的92例妇女作为对照组,应用化学发光法检测2组患者血清中促甲状腺素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)水平。结果:2组甲状腺功能亢进、甲状腺功能减退、低T4血症发生率差异无统计学意义(均P>0.05);观察组亚临床甲状腺功能减退、TPOAb(+)发生率均高于对照组,差异有统计学意义(P<0.05),与稽留流产有弱相关性(列联系数分别为0.21和0.22)。结论:甲状腺功能异常中的亚临床甲状腺功能减退、TPOAb(+)与稽留流产有一定的关系,提示开展妊娠早期甲状腺功能相关检查对降低稽留流产的发生率有一定临床意义。 Objective： To investigate the correlation between thyroid dysfunction and missed abortion. Methods：We choosed 95 patients diagnosed missed abortion whose gestational age less than 12 weeks as observation group, while 92 patients who have normal pregnancy as control group. Chemiluminescence method was used to detect the serum levels of thyrotropin hormone （TSH）, free thyroxine （FT4） and thyroid peroxidase antibody （TPOAb） in the two groups. Results： Comparing the incidence of hyperthyroidism, hypothyroidism and low thyroxine in both group, the difference was not statistically significant （P 〉0.05）. There were statistical differences of subclinical hypothyroidism and positive TPOAb incidence rate between observation group and control group（P〈0.05）, and they have weak correlations with missed abortion （correlation coefficients were 0.21 and 0.22）. Conclusious：There is correlation between thyroid dysfunction and missed abortion, the incidence of missed abortion is increased in subclinical hypothyroidism and positive TPOAb, so we should carry out the relevant checks thyroid function in pregnancy to reduce the incidence of missed abortion.

作者张立岩周晓刘爱红

机构地区山东省青岛市海慈医疗集团妇科

出处《国际妇产科学杂志》 CAS 2015年第2期207-208,共2页 Journal of International Obstetrics and Gynecology

关键词流产稽留甲状腺甲状腺功能减退症过氧化物酶类 Abortion, missed Thyroid gland Hypothyroidism Peroxidases

分类号 R714.21 [医药卫生—妇产科学] R581 [医药卫生—内分泌]

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