摘要
目的:研究中成药越鞠丸用于糖尿病前期患者"治未病"的临床疗效。方法:符合标准的216例糖尿病前期患者按随机数字表法分为观察组和对照组,所有患者均进行生活方式教育。对照组仅给生活方式干预,观察组在生活方式干预基础上给予越鞠丸口服并观察12个月。记录2组患者治疗前后血糖、血脂、血浆胰岛素、Hb A1C、计算胰岛素分泌指数及糖尿病前期患者血糖转归情况。结果:观察组FBG、P2Hbg、Hb A1C显著低于对照组,差异有统计学意义;血浆胰岛素及β细胞功能指数均显著高于对照组,差异有统计学意义;血脂指标观察组TC、TG、VLDL水平亦降低,与对照组比较差异有统计学意义;观察组糖尿病发病率(4.3%)显著低于对照组(10.3%),血糖转归正常(38.8%)远高于对照组(18.6%),差异有统计学意义。观察期均未出现严重不良反应。结论:越鞠丸口服联合生活方式改变能阻止糖尿病前期患者糖尿病的发生,值得临床推广应用。
Objective： To investigate the clinical effectiveness of Yue Ju Wan in patients with pre-diabetes. Methods： The selected 216 patients with pre-diabetes were randomly divided into two groups. Controal group （ n = 108） and observing group （n = 108）. Both were applied with life education of diabetes mellitus. Then ,control group was given single lifestyle intervention based on the control. It practiced as follow： Yue Ju Wan twice a day po, lasting for 12 months. The indexes of blood glucose and lipid ,insulin in plasma, HbA1C, Insulin secretion index（HOMA-IS）. Result： After treatment for 12 months. Decreasing of FBG,P2Hbg, HbA1C had significant difference compared with the control group. Increasing of insulin and serum insulin had significant difference compared with the control group, and the same with indexes of blood lipid which included TC, TG,VLDL. Incidence of diabetes mellitus of the observing group （4. 3% ） was lower than that of the control group （ 10.3% ） ,diabetes rate （38.8%） was higher than that of the control （ 18.6% ）. Both of the difference between the two groups was statistically significant. There were severe adverse events during the whole period. Conclusions ： It is effective to diabetes for the reason that it could prevent the process from pre-diabetes to diabetes mellitus and it should be widely used in clinical practice.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2015年第4期429-431,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
山东省卫生厅中医药科技发展计划资金资助项目(2013-324)
关键词
越鞠丸
糖尿病前期
治未病
Yue Ju Wan
Pre-Diabetes mellitus
prevention
