摘要
[目的]观察小柴胡汤+逐瘀利胆方治疗胆汁淤积型慢性乙型病毒性肝炎疗效。[方法]使用随机平行对照方法,将78例住院患者按就诊顺序号法简单随机分为两组。对照组39例肝功能检查,三元基因干扰素α-1b,500万IU/次,隔日1次,肌注。治疗组39例小柴胡汤(柴胡根15g,羌活10g,香附、瓜蒌各20g,郁金、半夏姜、南星各15g,黄芪30g,桂枝10g,荆芥穗20g,甘草5g);逐瘀利胆方(白术、柴胡根各15g,黄芪30g,郁金15g,桃仁20g,茵陈30g,大黄炒8g,滑石30g,车前子30g,甘草5g);均1剂/d,水煎200m L,早晚口服。连续治疗15d为1疗程。观测临床症状、ALT、AST、γ-GT、HBV-DNA阳性比、HBe Ag阳性比、不良反应。治疗1疗程(15d),判定疗效。[结果]治疗组痊愈15例,显效7例,有效12例,无效5例,总有效率87.18%。对照组痊愈12例,显效13例,有效4例,无效9例,总有效率76.92%。治疗组疗效优于对照组(P<0.05)。两组症状、体征积分均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]小柴胡汤+逐瘀利胆方治疗胆汁淤积型慢性乙型病毒性肝炎效果显著,值得推广。
[Objective]To observe Xiaochaihutang gallbladder stasis combined cholestatie Treatment of chronic hepatitis B treatment. [34rethods]Using random parallel control method, 78 cases of hospitalized patients with treatment order number method is simple and randomized into two groups. The control group 39 cases of liver function tests, three genes interferon ct-lb, 500 IU / times, every other day, intramuscularly. Treatment group 39 cases of Xiao Chai Hu Tang （Chaihugen 15g, Qianghuo 10g, Xiangfu,Gualou 20g, Yujin,Banxia,Dannanxing 15g, yellow stilbene 30g, Gui 10g, Nepeta ear 20g, licorice 5g ）; together gallbladder stasis party （Atractylodes, Bupleurum root of the 15g, yellow stilbene 30g, turmeric 15g, walnuts 20g, capillaris 30g, fried rhubarb 8g, tale 30g, Plantago 30g, licorice 5g）; both a agent / d, decoction 200mL, sooner or later orally. 15d is a continuous course of treatment. Observation of clinical symptoms, ALT, AST, y-GT, HBV-DNA-positive ratio, HBeAg- positive than adverse reactions. Treatment of a course of treatment （15d）, to determine efficacy. [Results] 15 cases were cured, effective in seven cases, effective 12 cases, ineffective in five cases, the total efficiency of 87.18%. Cured 12 cases in the control group, 13 cases markedly effective in 4 cases, nine cases, the total efficiency of 76.92%. Treatment group than the control group （P〈0.05）. Two sets of symptoms and signs were improved integration （P〈0.05）, improvement in the treatment group than the control group （P〈0.05）. [Conclusion] Xiaochaihutang together gallbladder stasis Treatment of chronic hepatitis cholestatic effect is significant, it is worth promoting.
出处
《实用中医内科杂志》
2015年第3期27-29,共3页
Journal of Practical Traditional Chinese Internal Medicine
