摘要
目的：检测大肠癌组织中 CD137、CD137L 和白细胞介素（IL）-2的表达，并探讨其对大肠癌发生和发展的作用。方法收集肠镜切除并经病理检查确诊的30例首发原发结直肠癌患者的癌组织、癌旁组织、远离癌肿的正常组织，采用免疫组织化学法检测其 CD137、CD137L 和 IL-2的表达。结果CD137在3种组织中均呈阴性表达。CD137L 在3种组织中的阳性表达率呈下降趋势（分别为80．0％、16．7％和0），差异有统计学意义（P ＜0．05），但不同年龄、性别、肿瘤大小、分化程度及肿瘤位置比较，CD137L 的表达差异无统计学意义（P ＞0．05）。CD137L 与 IL-2间无相关性。结论CD137L 在大肠癌组织及癌旁组织中的阳性表达率较高，CD137L 可能与大肠癌发生有关，对大肠癌早期诊断有一定的指导意义。
Objective To study the expressions of CD137 /CD137L,Interleukin （IL）-2 mole-cules in the colorectal cancer,and to analyze its clinicpathological significance in colorectal cancer.Meth-ods Using immunohistochemistry to investigate the expression of CD137 /CD137L,IL-2 in the colorectal cancer,border of the cancer,the control normal mucous,and to analyze its relationship with each other. Results CD137 expression was not found in all of them.The positive rate of CD137L expression was 80%,16.7%,0 respectively in colorectal cancer specimens,border cancer specimens,normal mucous. There were statistical difference（P 〈0.01）among colorectal cancer specimens and border cancer speci-mens,normal mucous.CD137L expression was not related to IL-2 expression.Conclusion Increased CD137L expression in colorectal cancer may play an important role in carcinogenesis of colorectal cancer, and is valuable to early diagnosis of colorectal cancer.
出处
《临床内科杂志》
CAS
2015年第4期260-262,共3页
Journal of Clinical Internal Medicine
