摘要
目的探讨白介素-33(IL-33)、白介素-37(IL-37)在鼻息肉中的表达及其在鼻息肉中发挥的作用。方法 40例鼻息肉患者的鼻息肉组织及18例鼻中隔偏曲患者的正常鼻黏膜组织为本次研究对象,用免疫组织化学方法分别检测其中IL-33及IL-37的表达情况。结果鼻息肉组IL-33阳性率为65.0%,IL-37阳性率为20.0%。正常鼻黏膜组中IL-33阳性率为33.3%,IL-37阳性率为77.8%。结论 IL-33、IL37与鼻息肉发病密切相关。
Objective To investigate the expression of IL-33,IL-37 in nasal polyps tissue,and their relevance to the pathogenesis of human nasal polyps. Methods Immunohistochemistry was used to detect the expression of IL-33,IL-37, in excisional nasal polyps tissue from 40 patients with nasal polyps. In addition,the expression of IL-33,IL-37 was also detected in normal nasal mucosa from 18 patients with the nasal septum deviation. Results In the nasal polyps tissues,IL-33 positive rate was 65.0%,IL-37 positive rate was 20.0%.In the normal nasal mucosa, IL-33 positive rate was 33.3%,IL-37 positive rate was 77.8%. Conclusion IL-33 and IL-37 play an important role in the pathogenesis of nasal polyps.
出处
《中国现代医生》
2015年第12期9-11,15,共4页
China Modern Doctor
