摘要
目的探讨来氟米特(LEF)和硫酸羟氯喹(HCQ)对狼疮性肾炎患者血脂水平影响的差异。方法选取2010年3月至2014年3月86例维持治疗期狼疮性肾炎患者,随机分为两组,各43例,分别予LEF和HCQ治疗,观察3个月,比较两组治疗前后血脂水平。结果 LEF组治疗前后血脂水平无显著差异(P>0.05);HCQ组治疗前后三酰甘油(TG)分别为(1.98±0.33)mmol/L比(1.74±0.36)mmol/L(P<0.01),总胆固醇(TC)为(4.69±0.65)mmol/L比(4.39±0.58)mmol/L(P<0.05);治疗前两组间各血脂成分无显著差异(P>0.05),治疗后LEF组和HCQ组TG分别为(1.91+0.35)mmol/L比(1.74±0.36)mmol/L(P<0.05),TC分别为(4.71±0.67)mmol/L比(4.39±0.58)mmol/L(P<0.05)。结论硫酸羟氯喹和来氟米特均能缓解狼疮肾炎患者的病情,但前者可降低患者血脂水平,从而减少心血管事件发生的风险。
Objective To compare the difference in the influences of leflunomide and hydroxychloroquine sulfate on blood lipid levels in the patients with lupus nephritis. Methods 86 patients with lupus nephrites treated by the maintenance treatment from March 2010 to March 2014 were randomly assigned to the leflunomide （ LEF ） group and the hydroxychloroquine sulfate （ HCQ ） group,each of them were 43 Cases. The two groups were respectively treated by leflunomide and hydroxychloroquine sulfate for 3 months. The blood lipid level before and after treatment were examined and compared between the two groups. Results The blood lipid levels in the LEF group has no statistical difference between before and after treatment （ P 〉 0. 05 ）;the blood lipid level after treatment in HCQ group has statistically significant statistical difference compared with before treatment [ triglyceride （ TG ）： （ 1. 98 ± 0. 33 ） vs. （ 1. 74 ± 0. 36 ） mmol/L, P 〈 0. 01; total cholesterol （ TC ）： （ 4. 69 ± 0. 65 ） vs. （ 4. 39 ± 0. 58 ） mmol/L, P 〈 0. 05 ]; the blood lipid levels before treat-ment had no statistically significant difference between the LEF group and the HCQ group （ P 〉 0. 05 ） , but the blood TG and TC levels after treatment had statistically significant differences between the two groups [ TG： （ 1. 91＋0. 35 ） mmol/L vs. （ 1. 74 ± 0. 36 ） mmol/L, P 〈 0. 05;TC： （ 4. 71 ± 0. 67 ） mmol/L vs. （ 4. 39 ± 0. 58 ） mmol/L, P 〈 0. 05 ] . Conclusion Hydroxychloroquine sulfate and leflunomide all relieve but the former can decrease the patient ’ s lipid level, thus reduce the cardiovascular risk.
出处
《中国药业》
CAS
2015年第9期37-38,共2页
China Pharmaceuticals
关键词
来氟米特
硫酸羟氯喹
狼疮性肾炎
血脂
leflunomide
hydroxychloroquine sulfate
lupus nephritis
blood lipid
