摘要
目的探讨多肿瘤标志物联合检测对肺癌诊断的临床价值。方法应用蛋白芯片法检测肺癌组(n=1 021)及健康体检者(n=827)血清中糖类抗原19-9(CA19-9)、癌胚抗原(CEA)、糖类抗原125(CA125)及糖类抗原15-3(CA15-3)的表达水平。结果不同病理类型肺癌中,4种血清肿瘤标志物在非小细胞肺癌中的阳性率均明显高于小细胞肺癌,差异有统计学意义(P<0.05)。CA19-9、CEA、CA125及CA15-3 4种肿瘤标志物单项检测对肺癌诊断的敏感性、特异性均不高;联合检测时诊断敏感性未见明显改善,但随着联合检测标志物种类的增加,特异性明显增加,均在98%以上。4项联合检测时对肺癌诊断具有最高的特异性(100%)。结论 CA19-9、CEA、CA125及CA15-3 4种肿瘤标志物联合检测能明显增加诊断的特异性。
Objective To discuss the clinical value of multi-tumor markers detection in the diagnosis of pulmonary carcino- ma. Methods The expression levels of serum CA19-9 ,CEA,CA125 and CA15-3 in 1 021 cases of pulmonary carcinoma and 827 in- dividuals of healthy physical examination were detected with multiple tumor markers chips. Results The positive rates of four tumor markers in nonsmall-cell lung cancer were significantly higher than thoset in small cell lung cancer, the differences between them showed statistical significance （P〈0.05）. Comparing the sensitivity and specificity between the single tumor marker detection and the multi-tumor markers detection, the single marker detection of CA19-9, CEA, CA125 and CA15-3 showed poor sensitivity and specificity for the diagnosis of pulmonary carcinoma; the sensitivity of their joint detection exhibited no obvious improvement, but with the increase of marker kinds in the joint detection, the specificity was significantly increased, which was more than 98 %. The joint detection of 4 markers had the highest specificity for diagnosing pulmonary carcinoma. Conclusion The joint detection of four tumor markers CA19-9,CEA,CA125 and CA15-3 can obviously increase the specificity of diagnosis.
出处
《重庆医学》
CAS
北大核心
2015年第13期1759-1761,共3页
Chongqing medicine
基金
四川省科技厅基金资助项目(2012SZ0058)
重庆市科技攻关资助项目(CSCQ
2009Ac5031)
关键词
肺肿瘤
癌胚抗原
抗原
癌相关
碳水化合物
lung neoplasms
carioembryonic antigen
antigens, tumor-associated, carbohydrate
