摘要
目的:观察健脾益气方对初诊2型糖尿病患者胰岛β细胞功能的影响。方法:90例初诊脾虚型2型糖尿病患者随机分为观察组及对照组,各45例。对照组给予糖尿病教育、饮食、运动治疗及胰岛素强化治疗,观察组患者对照组基础上给予健脾益气方,随访3个月。比较治疗后1个月、3个月两组患者血糖水平、糖化血红蛋白(haemoglobin A1c,Hb Alc)含量、胰岛素、C肽含量、胰岛素分泌指数(homeostasis model assessment-B,Homa-β)、胰岛素抵抗指数(Insulin resistance index,IRI)、脾虚证候积分。结果:观察组患者血糖水平、Hb Alc、C肽改善优于对照组,两组比较,差异有统计学意义(P<0.05)。观察组Homa-β升高、IRI降低明显,与对照组比较,差异有统计学意义(P<0.05)。观察组脾虚证候积分改善明显,与对照组患者比较,差异有统计学意义(P<0.05)。结论:健脾益气方对糖尿病患者胰岛β细胞具有一定程度的调节作用,能改善患者脾虚证候,效果满意。
Objective：To investigate the affection of isletβcell by Jianpiyiqi prescription for newly diagnosed type 2 diabetes. Methods ：90 cases of Spleen deficiency divided randomly into observation group and control group ,45cases in each group. Two groups were given dia- betes education, diet,exercise therapy and intensive instdin therapy. Patients in the observation group were given with Jianpiyiqi pre- scription based on this method. Compare with the two groups of patients＇ blood glucose level, glycosylated hemoglobin （ haemoglobin Alc ,HbAlc） content,Insulin, C peptide levels and Insulin secretion index （homeostasis model assessment-B, Homa-beta）, Insulin re- sistance index （Insulin to hold the index, IRI）, spleen deficiency syndrome integral after 1 month and 3 months. Results：Observation group of patients with blood glucose, HbAlc, C peptide improvement is superior to control group, two groups of comparison, the difference was statistically significant （P 〈 0.05 ）. In observation group, Homa-raised beta, and reducing IRI were obviously. Compared with con- trol group, the difference was statistically significant （ P 〈 0. 05 ）. Observation group of spleen deficiency were improved, compared with the control group patients, the difference was statistically significant （P 〈 0.05）. Conclusion ：Jianpiyiqi prescription has some degree of regulation for islet β ceils of diabetic patients, can
出处
《中医学报》
CAS
2015年第4期490-492,共3页
Acta Chinese Medicine
关键词
初诊2型糖尿病
健脾益气方
胰岛Β细胞
newly diagnosed type 2 diabetes
jianpiyiqi prescription
islet β cells
