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依达拉奉对大鼠创伤性脑损伤的早期保护作用 被引量：2

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摘要 目的探讨大鼠脑创伤后依达拉奉对脑组织的早期保护作用。方法选择雄性成年SD大鼠54只,随机分3组:假手术组18只,仅开骨窗,不损伤;损伤组18只,制大鼠自由落体脑撞击伤模型;依达拉奉组18只,行依达拉奉注射液处理。在伤后24h、48h及72h测量各组脑组织含水量、血脑屏障(BBB)通透性、丙二醛(MDA)含量、超氧化物歧化酶(SOD)活力。结果依达拉奉与损伤组比较,各时间点脑含水量减少、BBB通透性降低、MDA含量降低及SOD活力升高,差异有统计学意义(P<0.05)。结论依达拉奉对创伤性脑损伤早期有保护作用。
作者 周传广 冷晓磊 矫永庆 崔鹏
机构地区 辽宁大连市第三人民医院神经外科 大连医科大学附属三院神经外科
出处 《中国实用神经疾病杂志》 2015年第6期51-52,共2页 Chinese Journal of Practical Nervous Diseases
关键词 依达拉奉 创伤性脑损伤 脑含水量 血脑屏障通透性 丙二醛 超氧化物歧化酶活力
分类号 R651.15 [医药卫生—外科学]
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参考文献7

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中国实用神经疾病杂志
2015年 第6期

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