摘要
磷丙泊酚(fospropofol)为丙泊酚的前药,在体内经碱性磷酸酶水解后释放出丙泊酚,释放出来的丙泊酚具有独特的药理性质。安全性与有效性临床试验表明,该药的镇静作用与剂量成正比。磷丙泊酚使用剂量为6.5和8 mg/kg,用于结肠镜检、支气管镜检等内镜检查时镇静,疗效、安全性和耐受性都比较好;使用6.5 mg/kg剂量作为咪达唑仑的替代品用于口腔小手术时既镇静、安全且患者易于耐受。另外,磷丙泊酚用于老年患者支气管纤维镜检,不仅安全有效且患者苏醒快、满意度高,效果与年轻患者相似;采用静脉滴注/推注方式用于ICU患者短期麻醉诱导和镇静作用的维持,耐受性和有效性均可,也可以作为全身麻醉药用于行冠状动脉旁路移植手术患者。
Fospropofol is a prodrug of propofol which hydrolyzes in the body by alkaline phosphatase to liberate propofol. Propofol liberated from fospropofol has unique pharmacological properties. Fospropofol in doses of 6.5 or 8 mg/kg, is effective and well tolerated for the sedation of patients undergoing colonoscopy,flexible bronchoscopy. When administered intravenously by a dentist anesthesiologist at the indicated dose, it appearsed to be a safe, well-tolerated alternative to midazolam for intravenous moderate sedation during minor oral surgery procedures. In addition, fospropofol provides safe and effective sedation, rapid time to full alert, and high satisfaction in the elderly subset undergoing flexible bronchoscopy, which is comparable with outcomes in younger patients. Study suggested that fospropofol, administered in an infusion/bolus regimen, be tolerable and effective for short-term induction and maintenance of sedation in intensive care unit patients. Fospropofol also could be used to provide general anesthesia in patients undergoing coronary artery bypass graft surgery.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2015年第2期165-169,共5页
Journal of International Pharmaceutical Research
关键词
磷丙泊酚
丙泊酚
镇静
麻醉性监护
fospropofol
propofol
sedation
monitored anesthesia-care
