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特发性肺纤维化发病机制及药物治疗的研究进展 被引量：19

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摘要 特发性肺纤维化（idiopathic pulmonary fibrosis,IPF）是一种病因不明的慢性进行性肺间质疾病,好发于老年人。其特征主要为进行性的呼吸困难及肺功能下降、高分辨率CT（high-resolution computed tomography,HRCT）显示下肺组织呈进行性纤维化[1-2]。IPF患者预后极差,一般生存期为确诊后的2至3年,发病率约为每10万人中6.8~16.3人,
作者 孙锦涛 徐兴祥
机构地区 扬州大学临床医学院
出处 《中华肺部疾病杂志（电子版）》 CAS 2015年第2期82-87,共6页 Chinese Journal of Lung Diseases(Electronic Edition)
基金 国家自然科学基金(81302016)
关键词 特发性肺纤维化 发病机制 药物治疗
分类号 R563 [医药卫生—呼吸系统]
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参考文献78

  • 1任成山（综述）,钱桂生（审校）.慢性阻塞性肺疾病发病机制研究现状与展望[J].中华肺部疾病杂志（电子版）,2009,2(2):83-92. 被引量：127
  • 2崔社怀.特发性肺间质纤维化的回顾和展望[J].中华肺部疾病杂志（电子版）,2010,3(1):4-5. 被引量：22
  • 3Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management[ J]. Am J Respir Crit Care Med, 2011, 183(6) : 788-824.
  • 4Borensztajn K, Crestani B, Kolb M. Idiopathic pulmonary fibrosis: from epithelial injury to biomarkers-insights from the bench side [ J ]. Respiration, 2013, 86(6): 441-452.
  • 5Sime PJ, Xing Z, Graham FL, et al. Adenovector-mediated gene transfer of active transforming growth factor-betal induces prolonged severe fibrosis in rat lung[J]. J Clin Invest, 1997, 100(4) : 768- 776.
  • 6Raghu G, Brown KK, Costabel U, et al. Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory , placebo controlled trial[J]. Am J Respir Crit Care Med, 2008, 178(9) : 948-955.
  • 7Idiopathic Pulmonary Fibrosis Clinical Research Network, Raghu G, Anstrom KJ, et al. Prednisone, azathioprine, and N-acetyleysteine for pulmonary fibrosis[J]. N Engl J Med, 2012, 366(21 ) : 1968- 1977.
  • 8Woodcock HV, Molyneaux PL, Maher TM. Reducing lung function decline in patientswith idiopathic pulmonary fibrosis: potential of nintedanib[ J]. Drug Des Devel Ther, 2013, 7: 503-510.
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共引文献147

同被引文献224

  • 1杨礼腾,程德云,方洵,穆茂,聂莉,胡小波.肾阳虚肺纤维化和肺纤维化大鼠肺组织糖皮质激素受体的表达[J].时珍国医国药,2006,17(8):1448-1451. 被引量：13
  • 2Kolb M, Co|lard HR. Staging of idiopathic pulmonary fibrosis: past, present and future [ J ]. Eur Respir Rev, 2014, 23 ( 132 ) :220-224.
  • 3Ryu JH, Moua T, Daniels CE, et al. Idiopathic pulmonary fibrosis: evolving concepts [ J ]. Mayo Clin Proc, 2014, 89 (8) : 1130-1142.
  • 4Yang IV, Schwartz DA. Epigeneties of idiopathic pulmonary fibrosis [J]. Transl Res, 2015, 165(1) : 48-60.
  • 5Wolters PJ, Collard HR, Jones KD. Pathogcnesis of idiopathic pulmonary fibrosis[J]. Annu Rev Pathol, 2014, 9: 157-179.
  • 6Piccirillo CA. Regulatory T cells in health and disease[J]. Cytokine, 2008, 43(3) : 395-401.
  • 7Cools N, Ponsaerts P, van Tendeloo VF, et al. Regulatory T cells and human disease[ J]. Clin Dev Immunol, 2007, 2007: 89195.
  • 8Tang YJ, Xiao J, Huang XR, et al. Latent transforming growth factor-IM protects against bleomycin-induced lung injury in mice [J]. Am J Respir Cell Mol Biol, 2014, 51(6) : 761-771.
  • 9Szema AM, Reeder R J, Harrington AD, et al. Iraq dust is respirable, sharp, and metal-laden and induces lung inflammation with fibrosis in mice via IL-2 upregulation and depletion of regulatory T cells [ J ]. J Oceup Environ Med, 2014, 56(3) : 243-251.
  • 10Lo Re S, Lecoeq M, Uwambayinema F, et al. Platelet-derived growth factor-producing CD4 + Foxp3 + regulatory T lymphoeytes promote lung fibrosis[J]. Am J Respir Crit Care Med, 2011, 184 ( 11 ) : 1270-1281.

引证文献19

二级引证文献94

中华肺部疾病杂志（电子版）
2015年 第2期

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