摘要
以介孔分子筛MCM-41为基质,黄芩苷(BA)为模板分子,丙烯酰胺(AM)为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联剂,乙醇为溶剂,在偶氮二异丁腈(AIBN)的引发下进行热聚合,合成一种具有选择性识别黄芩苷的表面分子印迹聚合物。采用傅立叶红外光谱(IR)和透射电镜(TEM)对印迹聚合物的形态和结构进行表征,通过动态吸附和静态吸附实验研究了印迹聚合物的吸附能力。结果表明,成功合成的黄芩苷表面分子印迹聚合物仍然保留了MCM-41的介孔结构,并且对黄芩苷具有良好的吸附能力,为从天然药物黄芩中高效分离富集黄芩苷提供一种新材料。
Taking mesoporous molecular sieve MCM-41 as a substrate, baicalin （BA） as template, acrylamide （AM） as the func- tional monomer, ethylene glycol dimethacrylate （EGDMA） as a cross-linking agent, ethanol as solvent, under thermal polymerization initiator of azobis isobutyronitrile （AIBN） , a kind of selective recognition of baicalin surface molecularly imprinted polymer was synthe- sized. The surface morphologies and characteristics of the MIPs were characterized by infrared spectroscopy （IR） and transmission electron microscope（TEM）. The adsorption properties of polymer microsphere for the template were tested by the dynamic adsorption equilibrium experiments and static adsorption equilibrium experiments. The experiment showed that the imprinting process was success- fully and the well-ordered one-dimensional pore structure of MCM-41 was still preserved. Furthermore, molecularly imprinted polymers had higher selective ability for BA, then provided a new method for the efficient separation and enrichment of baicalin active ingredients from medicinal plants Scutellaria baicalensis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第9期1718-1722,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30801558
81373895
81173538)
关键词
分子印迹技术
MCM-41
黄芩苷
吸附特性
molecular imprinting technique （MIT）
MCM-41
baicalin
adsorption characteristic
