摘要
目的检测动脉粥样硬化患者人巨细胞病毒感染情况,分析人巨细胞病毒感染与颈动脉粥样硬化发生的相关性,探讨病毒病因可能导致动脉粥样硬化的发病机制。方法选取142例动脉粥样硬化患者为观察组,同期选取70例健康体检患者为对照组,采用ELISA法检测其血清HCMV抗原,放射免疫法检测TNF-α含量,比较单支病变患者与多支病变患者HCMV感染率和TNF-α含量的差异。结果观察组HCMV感染检测阳性率为41.5%,高于对照组的18.6%,差异有统计学意义(χ2=11.038,P<0.05),观察组中颈动脉单支病变HCMV感染阳性率32.8%,低于多支病变的48.1%,差异有统计学意义(χ2=3.381,P<0.05),观察组中HCMV感染阳性患者的TNF-α为(3.03±0.36)μg/L,高于HCMV感染阴性患者的(1.24±0.30)μg/L,差异有统计学意义(t=18.254,P<0.01)。且TC、TG、HDL-C及LDL-C水平均高于感染阴性患者,差异均有统计学意义(P<0.05)。结论人巨细胞病毒感染可能会导致患者的血脂异常及血管内皮细胞损伤,从而参与颈动脉粥样硬化的发生与发展。
Objective To detect the status of human cytomegalovirus（HCMV） infection and analyze its correlation withcarotid atherosclerosis and explore the pathogenesis of atherosclerosis associated with cytomegalovirus infection. Methods One hundred and twenty-one patients with atherosclerosis was selected as the observation group, 70 healthy patients as thecontrol group. HCMV was detected by ELISA and concentration of TNF-α was detected by radioimmunoassay. The differencesin infection rate and concentrations of TNF- α between single- vessel disease and multiple vessel disease was compared.Results The positive rate of HCMV infection in the observation group（41.5%） was higher than that of the control group（18.6%） with statistically significant difference（χ2= 11.038, P 〈0.05）. HCMV infection rate in the patients with carotid singlevessel disease in the observation group（32.8%） was lower than that of multiple vessel disease（48.1%）, showing statisticallysignificant difference（χ2= 3.381, P 〈0.05）.The concentrqtion of TNF-α in HCMV-positive patients in observation group [（3.03± 0.36） μg / L] was higher than of HCMV-negative patients [（1.24 ± 0.30） μg / L] with statistically significant difference（t=18.254, P 〈0.01）. TC, TG, HDL-C and LDL-C levels in HCMV-positive patients were higher than HCMV-negative patients,with statistically significant differences（P 〈0.05）. Conclusion The human cytomegalovirus infection may lead todyslipidemia and endothelial injury in the patients and it also involved in the occurrence and development of carotidatherosclerosis.
出处
《中国热带医学》
CAS
2015年第3期370-371,376,共3页
China Tropical Medicine
关键词
动脉粥样硬化
高血压
人巨细胞病毒
感染
Atherosclerosis
Hypertension
Human cytomegalovirus
Infection
