摘要
目的探讨哮喘控制测试(asthma control test,ACT)评分与非过敏性哮喘患者诱导痰液中超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)及气道反应性的相关性。方法选择135例非过敏性哮喘患者(非过敏性哮喘组)及50例同期健康体检者(对照组),检测2组痰液中hs-CRP含量及肺功能情况。再依据入院时ACT评分将非过敏性哮喘患者分为2组,A组58例(ACT评分≥20),B组77例(ACT评分<20),并检测其气道反应性。采用Pearson相关检验分析ACT评分与hs-CRP及气道反应性的相关性。结果非过敏性哮喘患者痰液中hs-CRP含量明显高于对照组,而肺功能各指标FEV1、FEV1%、PEF及PEF%则显著低于对照组(均P<0.01)。非过敏性哮喘B组患者痰液中hs-CRP水平较A组高(P<0.01),而反映气道反应性的FEV1改变量均显著低于A组(P<0.05)。ACT评分与hs-CRP含量呈负相关(r=-0.76,P<0.01),与FEV1增加程度(%)和绝对值增加量(mL)呈正相关(r=0.85,P<0.05;r=0.916,P<0.05)。结论 ACT评分与非过敏性哮喘患者升高的hs-CRP水平及气道反应性密切相关,正确使用该评分有助于简便、快捷地进行病情评估。
ABSTRACT:Objective To investigate the correlations of asthma control test(ACT)scores with sputum high-sensitivity C-reactive protein(hs-CRP)levels and airway reactivity in patients with nonallergic asthma.Methods The hs-CRP contents in sputum and pulmonary function were measured in 135 patients with nonallergic asthma(nonallergic asthma group)and 50 healthy sub-jects(control group).According to the ACT score,patients with nonallergic asthma were further divided into two groups:group A(ACT score≥20,n=58)and group B(ACT score<20,n=77). The airway reactivity was determined in both groups.The correlations of ACT scores with spu-tum hs-CRP contents and airway reactivity were analyzed by Pearson correlation analysis.Results Compared with control group,the hs-CRP contents in sputum increased and the FEV1,FEV1%, PEF and PEF% decreased in nonallergic asthma group(P <0.01).Compared with group A,the hs-CRP contents in sputum increased and the change in FEV1 decreased in group B(P <0.01 or P <0.05).The ACT scores were negatively correlated with the hs-CRP levels(r = -0.76,P <0.01),but positively correlated with the increased degree(%)and amount(mL)of FEV1 (r =0.85,P <0.05 and r =0.916,P <0.05,respectively ).Conclusion The ACT scores are closely correlated with sputum hs-CRP levels and airway reactivity in patients with nonallergic asthma. Therefore,ACT scores can be used as a simple measure to assess the development of nonallergic asthma.
出处
《南昌大学学报（医学版）》
CAS
2015年第2期51-53,57,共4页
Journal of Nanchang University：Medical Sciences
关键词
非过敏性哮喘
ACT
评分
超敏
C
反应蛋白
气道反应性
nonallergic asthma
asthma control test scores
high-sensitivity C-reactive protein
airway reactivity
