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血清孕酮、胰岛素生长因子-Ⅱ在预测妊娠早期不良结局中的作用 被引量:13

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摘要 目的:探讨血清孕酮(progesterone,P)、胰岛素生长因子-Ⅱ(insulin growth factorⅡ)在预测妊娠早期不良结局中的作用。方法:采用化学发光免疫分析及放射免疫法分别检测42例健康早孕妇女(A组)和85例具有先兆流产症状给予保胎治疗的早孕妇女P、IGF-Ⅱ水平,其中保胎成功45例(B组)、发展为稽留流产40例(C组)。比较各组数值的相关性。应用ROC曲线对P、IGF-Ⅱ进行分析评价。结果:(1)A、B、C 3组血清孕酮的值分别为(30.36±2.96)、(23.88±2.26)、(11.43±2.46)ng/m L,血清IGF-Ⅱ的值分别为:(139.29±16.44)、(123.93±16.14)、(107.94±12.87)μg/L,3组P、IGF-Ⅱ值均具有差异性(F=571.69和43.05,均P<0.05);(2)A、C两组血清中P和IGF-Ⅱ存在正相关(r=0.732、0.942,均P<0.05),B组两者不具有相关性(r=0.199,P=0.191,P>0.05);(3)P、IGF-Ⅱ判断活胎和胚胎停止发育最佳诊断点分别为:13.42 ng/m L,121.26μg/L。结论:血清P联合IGF-Ⅱ测定在预测胚胎及胎儿早期发育中有一定的价值。
出处 《实用医学杂志》 CAS 北大核心 2015年第8期1251-1253,共3页 The Journal of Practical Medicine
基金 河南省卫生科技中青年创新人才工程资助项目(编号:201004122)
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参考文献11

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共引文献38

同被引文献127

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