摘要
目的:探讨超声导入氨甲环酸治疗黄褐斑疗效及安全性。方法:黄褐斑患者109例随机分为治疗组(n=55)和对照组(n=54),治疗组采用超声导入氨甲环酸治疗黄褐斑,对照组采用维A酸乳膏治疗。总疗程为12周,观察两组患者治疗后不良反应及不同时段的总有效率。结果:治疗4、8、12周后,治疗组总有效率(27.27%、36.36%、58.18%)均显著高于对照组(11.11%、18.52%、35.19%)。结论:维A酸乳膏联合胶原贴敷料治疗黄褐斑治疗效果明显优于单用维A酸乳膏,且减轻了维A酸乳膏的不良反应。
Objective:To observe the clinical efficacy and safety of treatment of chloasma by phonophoresis with tranexamic acid Methods:A total of 109 patients of chloasma were randomly divided into the treatment group n=55)and the control group(n=54).The patients in treatment group had been treated with tranexamic acid by phonophoresis while the control group had been treated with0.1% Tretinoin cream only.The course of treatment had been 12 weeks.The total effective rate and side-effects at different time points had been observed.Results:4weeks,8weeks and 12 weeks later,the efficiency of treatment group were 27.27%,36.36%,58.18% respectively,which were all significantly higher than those of the control group(11.11%,18.52%,35.19% respectively,P<0.05).Conclusion:Phonophoresis with tranexamic acid is effective and safe for patients with chloasma,which is much better than only application of Tretinoin cream with less side-effects.
基金
东莞市科技计划医疗卫生类科研一般项目(201210515000228)
