摘要
目的：分析万古霉素鞘内注射与持续腰大池引流对高血压脑出血术后颅内感染患者的治疗疗效，为临床诊治提供参考。方法选择2011－2013年巴州人民医院收治的76例高血压脑出血术后颅内感染患者，将其随机分成观察组和对照组，各38例，两组患者均使用万古霉素鞘内注射，观察组在万古霉素鞘内注射基础上给予腰大池持续引流，引流时间为1～2周，比较两组患者的感染控制及临床疗效。结果两组患者脑脊液成分在治疗前比较差异无统计学意义；治疗后脑脊液中白细胞、蛋白质含量均有显著降低，葡萄糖含量有显著升高，两组患者治疗前后脑脊液成分比较差异有统计学意义（ P＜0．05）；治疗后的总有效率观察组为92．11％、对照组为76．32％，两组患者的疗效差异有统计学意义（ P＜0．05）。结论持续腰大池引流联合万古霉素鞘内注射治疗高血压脑出血术后颅内感染具有显著的疗效，能明显改善患者的感染症状，适合在临床上推广应用。
OBJECTIVE To evaluate the effect of intrathecal injection of vancomycin combined with continuous lum‐bar drainage on treatment of the hypertensive intracerebral hemorrhage patients with postoperative intracranial in‐fections so as to provide guidance for clinical diagnosis and treatment .METHODS A total of 76 hypertensive intrac‐erebral hemorrhage patients with postoperative intracranial infections who were treated in the Xinjiang Korla Peo‐ple′s Hospital from 2011 to 2013 were enrolled in the study and randomly divided into the observation group and the control group ,with 38 cases in each .Both groups were treated with intrathecal injection of vancomycin ,while the observation group was given additional continuous lumbar drainage on the basis of the intrathecal injection of vancomycin ,with the drainage duration of 1 to 2 weeks .The clinical effect on control of infections was observed and compared between the two groups of patients .RESULTS There was no significant difference in the composition of cerebrospinal fluid between the two groups before the treatment ;the contents of white blood cells and protein in the cerebrospinal fluid were significantly reduced after the treatment ,while the content of glucose was significantly elevated （P〈0 .05） .The total effective rate of treatment was 92 .11% in the observation group ,76 .32% in the control group , and there was significant difference in the efficacy between the two groups （ P〈0 .05 ） . CONCLUSION Continuous lumbar drainage combined with intrathecal injection of vancomycin can achieve signifi‐cant effect on treatment of the hypertensive intracerebral hemorrhage patients with postoperative intracranial infec‐tions and remarkably improve the symptoms of the patients with infections ,and it is worthy to be promoted in the hospital .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第9期1999-2001,共3页
Chinese Journal of Nosocomiology
基金
新疆维吾尔自治区自然科学基金资助项目(2011211A591)
关键词
高血压
颅内感染
持续腰大池引流
鞘内注射
万古霉素
Hypertension
Intracranial injection
Continuous lumbar drainage
Intrathecal injection
Vancomycin
