摘要
目的:研究和比较癃清片不同溶剂提取物的抗炎镇痛作用。方法:采用二甲苯致小鼠耳肿胀、角叉菜胶诱导小鼠足肿胀进行抗炎实验,采用热板法和醋酸扭体法进行镇痛实验,比较癃清片醇提取物、水提取物、二氯甲烷和正丁醇部位的抗炎镇痛作用。结果:癃清片醇提物、水提物均具有不同程度的抗炎镇痛作用,同剂量之间比较以醇提取物活性较强。癃清片正丁醇部位(0.23g/kg、0.46g/kg)能明显降低二甲苯致炎小鼠血清中PGE2、MAD、TNF-α含量,醇提正丁醇部位(0.46g/kg)抑制角叉菜胶致小鼠足趾肿胀,该部位(0.12g/kg、0.23g/kg、0.46g/kg)能延长热板所致的小鼠舔后足的时间,该部位(0.23g/kg、0.46g/kg)减少醋酸致小鼠扭体反应的次数。结论:癃清片具有明显的抗炎镇痛活性,醇提取物的正丁醇部位可能是其一个有效部位。
Objective： To observe the anti-inflammatory and analgesic effects of different extraction from Long Qing tablet. Methods： Mice models of xylene-induced ear swelling and carrageen-induced pedal edema were used to evaluate anti-inflammatory activity. The analgesic activity in mice was evaluated with writhing response caused by acetic acid and with hot-plate test. The anti-inflammatory and analgesic effects were compared in alcohol extract and water extract of Long Qing tablet and two extracts by different solvents such as petroleum dichloromethane and nbutyl alcohol. Results： Both alcohol extract and water extract were showed anti-inflammatory and analgesic activity,but the effect of alcohol extract（ 0. 23 g / kg,0. 46 g / kg） was stronger than that of water extract at the same dose. N-butyl alcohol extract（ 0. 12 g / kg ~ 0. 46 g / kg） were showed anti-inflammatoty activities,prolonged the time period of paw-licking,and reduced the writhing frequency. Conclusion： Long Qing tablet has significant anti-inflammatory and analgesic activity,and n-butyl alcohol extract may be the effective parts.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2015年第1期213-217,共5页
Pharmacology and Clinics of Chinese Materia Medica
关键词
癃清片
极性部位
抗炎
镇痛
Longqing Tablet（癃清片）
activityparts
anti-inflammatory
analgesia
